Green tea supplementation upregulates uncoupling protein 3 expression in severe obese women adipose tissue but does not promote weight loss

Autor(es):Mostrar menos -

Gomes Quinhoneiro, Driele Cristina ^[1] ; Nicoletti, Carolina Ferreira ^[1] ; Souza Pinhel, Marcela Augusta ^[1] ; Noronha, Natalia Yumi ^[1] ; Moreno Braga, Camila Bitu ^[1] ; Parenti Oliveira, Bruno Affonso ^[1] ; Cortes-Oliveira, Cristiana ^[1] ; Oliveira, Wanderley Pereira ^[2] ; Salgado Junior, Wilson ^[3] ; Marchini, Julio Sergio ^[1] ; Nonino, Carla Barbosa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Pharmaceut Sci, Ribeirao Preto - Brazil

^[3] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Surg & Anat, Ribeirao Preto - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION; v. 69, n. 8, p. 995-1002, NOV 17 2018.
• Citações Web of Science: 6

Resumo

This study aims (i) to verify expression of the UCPs, PLIN1, PPARG2, and ADRB3 genes in the abdominal subcutaneous adipose tissue of obese women at baseline and after 8 weeks of supplementation with decaffeinated green tea extract, and (ii) to associate findings with clinical parameters. This is a longitudinal study during which 11 women with obesity grade III were submitted to supplementation with 450 mg of (-)-epigallocatechin gallate (EGCG) (intervention group); the control group consisted of 10 eutrophic women. Anthropometric parameters {[}weight, height, and body mass index (BMI)], resting metabolic rate (RMR, measured by indirect calorimetry), and gene expression (measured by real-time PCR, RT-qPCR) were determined before and after supplementation. After 8 weeks, clinical parameters and UCP1, PLIN1, PPARG2, and ADRB3 expression remained unaltered in the intervention group (p > .05). Genetic analysis also showed that the UCP3 gene was upregulated (p = .026), but its upregulation did not promote weight loss. (AU)

• Processo FAPESP: 14/00669-0 - Análise da expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após a suplementação com chá verde
• Beneficiário: Driele Cristina Gomes Quinhoneiro
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/08916-4 - Análise da expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso
• Beneficiário: Carla Barbosa Nonino
• Linha de fomento: Auxílio à Pesquisa - Regular