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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Basic reproduction number for the Brazilian Spotted Fever

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Autor(es):
Polo, Gina ; Labruna, Marcelo B. [1] ; Ferreira, Fernando
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Dept Prevent Vet Med & Anim Hlth, Lab Parasit Dis, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Theoretical Biology; v. 458, p. 119-124, DEC 7 2018.
Citações Web of Science: 4
Resumo

Brazilian Spotted Fever (BSF) is an emerging and lethal disease in South America which basic reproduction number (R-0) is unknown. Calculating R-0 for this disease is crucial to design control interventions and prevent human deaths. BSF endemic areas are related to the presence of capybaras Hydrochoerus hydrochaeris, amplifier hosts of Rickettsia rickettsii and primary hosts of the tick Amblyomma sculptum, main vector of the agent in this area. Because of the complexity of its dynamics, we calculated R-0 for the BSF system by constructing a next-generation matrix considering different categories of vectors and hosts. Each matrix element was considered as the expected number of infected individuals of one category produced by a single infected individual of a second category. We used field and experimental data to parameterize the next-generation matrix and obtain the final calculation (R-0 approximate to 1.7). We demonstrated the low impact of the matrix elements corresponding to the transovarial transmission and the transmission from infected larvae in the maintenance of R. rickettsii. Sensitivity and elasticity analyzes were performed to quantify the perturbations of each matrix element in R-0. We noted that the elements equivalent to the number of infected attached nymphs produced by an infected capybara, and the number of infected capybaras produced by an infected attached nymph or adult are the major contributors to changes in R-0. Our results provide insights into the strategic design of preventive interventions in BSF endemic areas. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 13/18046-7 - Capivaras, carrapatos e febre maculosa
Beneficiário:Marcelo Bahia Labruna
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/12213-1 - Modelagem e simulação estocástica para o estudo da dinâmica de Rickettsia rickettsii em populações de Hydrochoerus hydrochaeris e de Amblyomma cajennense no estado de São Paulo
Beneficiário:Gina Paola Polo Infante
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 16/01913-8 - Modelo metapopulacional da dinámica de Rickettsia rickettsii em subpopulações de capivaras estruturadas espacialmente
Beneficiário:Gina Paola Polo Infante
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado