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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

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Autor(es):
Diniz, Miriely S. [1] ; Teixeira-Neto, Francisco J. [2] ; Goncalves, Daniele S. [2] ; Celeita-Rodriguez, Nathalia [1] ; Girotto, Carolina H. [1] ; Fonseca, Mariana W. [1] ; Takahira, Regina K. [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Fac Med, Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF VETERINARY INTERNAL MEDICINE; v. 32, n. 6, p. 1927-1933, NOV-DEC 2018.
Citações Web of Science: 1
Resumo

Background Objective Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. Animals Methods Six healthy English Pointer dogs (19.7-35.3 kg). Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs). Results Conclusions and Clinical Relevance Buccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa-angle increased from controls from 0.5 to 4 hours after LRS (CFT, P <= 0.0001-0.02; alpha angle, P = 0.0001-0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002-0.01; alpha angle, P = 0.0005-0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P <= 0.0001-0.01) and TS (P <= 0.0001-0.04). Tetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum. (AU)

Processo FAPESP: 14/25115-8 - Uma abordagem dos paradigmas da fluidoterapia no período perioperatório em pequenos animais
Beneficiário:Francisco José Teixeira Neto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/04810-2 - Avaliação do hidroxietilamido de terceira geração (Tetrastarch) em relação ao Ringer Lactato como fluido de reposição em animais sadios submetidos à hemodiluição normovolêmica aguda
Beneficiário:Miriely Steim Diniz
Linha de fomento: Bolsas no Brasil - Doutorado