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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum

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Autor(es):
da Silva, Diogo Tiago [1, 2] ; Alves, Maria Luana [1, 2] ; Pereira Spada, Julio Cesar [1, 2] ; Viveiros da Silveira, Rita de Cassia [3] ; Ferreira de Sousa Oliveira, Tricia Maria [2, 4] ; Starke-Buzetti, Wilma Aparecida [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Fac Engn Ilha Solteira, Dept Biol & Ciencia Anim, Ave Brasil 56, BR-15385000 Ilha Solteira, SP - Brazil
[2] Univ Sao Paulo, Programa Grad Epidemiol Expt Aplicada Zoonoses, Sao Paulo, SP - Brazil
[3] Univ Estadual Paulista UNESP, Inst Biotechnol, Botucatu, SP - Brazil
[4] Univ Sao Paulo, Dept Med Vet, Fac Engn Alimentos & Ciencia Anim FZEA, Pirassununga, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: Revista Brasileira de Parasitologia Veterinária; v. 27, n. 4, p. 430-438, OCT-DEC 2018.
Citações Web of Science: 1
Resumo

Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophi Is, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. infantum amastigotes in the intestine; group 2 (G2, n=9), dogs with CVL but without intestinal amastigotes; and group 3 (G3, n=3), uninfected dogs (control group). Granulocytic cells were counted in the crypt-villus unit (mucosa), submucosa, and muscle layer of the intestinal mucosa. Cell counts were higher in the intestinal wall of dogs from G2 followed by G1 and G3 (p <= 0.05). In G1, there was a low inverse correlation between parasite burden of the small intestine and granulocyte counts (r= -0.1, p <= 0.01). However, in G2 dogs, mast cell and eosinophil numbers showed positive correlation (r=0.85, p <= 0.01). The granulocytic cell hyperplasia observed in the intestine of L. infantum-infected dogs suggests that these cells may be involved in the cell-mediated immune response for parasite elimination. (AU)

Processo FAPESP: 13/13875-5 - Correlação do perfil das células granulocíticas e monocíticas no intestino de cães naturalmente infectados por Leishmania infantum
Beneficiário:Diogo Tiago da Silva
Linha de fomento: Bolsas no Brasil - Mestrado