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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Circulating Tissue Inhibitor of Metalloproteinase-4 levels are not a Predictor of Preeclampsia in the period between 20 and 25 Weeks of Gestation

Texto completo
Autor(es):
Sandrim, Valeria Cristina [1] ; Machado, Jackeline [2] ; Bettiol, Heloisa [2] ; Barbier, Marco Antonio [2] ; Cardos, Viviane Cunha [2] ; Palei, Ana Carolina [3] ; Cavalli, Ricardo Carvalho [2]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, Dist Rubiao Jr S-N, BR-18618000 Botucatu, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto, SP - Brazil
[3] Univ Mississippi, Med Ctr, Jackson, MS 39216 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Revista Brasileira de Ginecologia e Obstetrícia; v. 40, n. 12, p. 757-762, DEC 2018.
Citações Web of Science: 0
Resumo

Objective To evaluate whether the circulating level of tissue inhibitor of metalloproteinase-4 (TIMP-4) in the period between 20 and 25 weeks of gestation is a predictor of preeclampsia. Methods We have performed a case-control study, nested in a prospective study cohort in Ribeirao Preto, in the state of Sao Paulo, Brazil. Of the 1,400 pregnant women evaluated between 20 and 25 weeks of gestation, 460 delivered in hospitals outside of our institution. Of the 940 pregnant women who completed the protocol, 30 developed preeclampsia. Healthy pregnant women (controls, n = 90) were randomly selected from the remaining 910 participants. From blood samples collected between 20 and 25 weeks of gestation, we performed a screening of 55 angiogenesis-related proteins in 4 cases and 4 controls. The protein TIMP-4 was the most differentially expressed between cases and controls. Therefore, we measured this protein in all cases (n = 30) and controls selected (n = 90). Results There were no differences in the plasma TIMP-4 levels of cases compared with controls (1,144 +/- 263 versus 1,160 +/- 362 pg/mL, respectively; p > 0.05). Conclusion Plasma TIMP-4 levels were not altered at 20 to 25 weeks of gestation, before the manifestation of clinical symptoms; therefore, they are not good predictors of the development of preeclampsia. (AU)

Processo FAPESP: 08/53593-0 - Fatores etiológicos da prematuridade e conseqüências dos fatores perinatais na saúde da criança: coortes de nascimentos em duas cidades brasileiras
Beneficiário:Marco Antonio Barbieri
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/20461-8 - Papel do Nrf2 e HO-1 em pré-eclâmpsia: estudo de polimorfismos genéticos, fatores circulantes e ensaios in vitro
Beneficiário:Valeria Cristina Sandrim
Linha de fomento: Auxílio à Pesquisa - Regular