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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Depressant effect of geraniol on the central nervous system of rats: Behavior and ECoG power spectra

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Autor(es):
Medeiros, Katty Anne A. L. [1] ; dos Santos, Jose R. [2] ; Melo, Thais Cristina de S. [3] ; de Souza, Marina F. [1] ; Santos, Luciano de G. [1] ; de Gois, Auderlan M. [1] ; Cintra, Rachel R. [1] ; Lins, Livia Cristina R. F. [1] ; Ribeiro, Alessandra M. [4] ; Marchioro, Murilo [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Grad Program Physiol Sci, Itabaiana, SE - Brazil
[2] Univ Fed Sergipe, Behav & Evolutionary Neurobiol Lab, Dept Biosci, Itabaiana, SE - Brazil
[3] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Med, Itabaiana, SE - Brazil
[4] Univ Fed Sao Paulo, Dept Biosci, Santos, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: BIOMEDICAL JOURNAL; v. 41, n. 5, p. 298-305, OCT 2018.
Citações Web of Science: 2
Resumo

Geraniol is a monoterpene alcohol that is derived from the essential oils of aromatic plants, with anti-inflammatory, antimicrobial, antioxidant and neuroprotective properties. This study characterized the effect of geraniol on behavior and brainwave patterns in rats. Male rats were submitted to administration of geraniol (25, 50 and 100 mg/kg). The hole board (HB) and open field (OF) tests were performed to evaluate anxiety and motor behavior, respectively. In addition, barbiturate-induced sleeping time (BIST) was used to analyze sedative effect. Finally, electrocorticogram (ECoG) recordings were used to characterize brain-wave patterns. The results showed that geraniol treatment in rats decreased the distance traveled, rearing numbers and lead to increase in immobility time in HB and OF tests. In BIST test, geraniol treatment increased sleep duration but not sleep latency in the animals. Furthermore, geraniol-treated animals demonstrated an increase in the percentage of delta waves in the total spectrum power. Taken together, our results suggested that geraniol exerted a depressant effect on the central nervous system of rats. (AU)

Processo FAPESP: 15/20785-8 - Bioprospecção de produtos de origem natural com potencial atividade neuroprotetora em modelos animais de epilepsia e doença de Parkinson.
Beneficiário:Alessandra Mussi Ribeiro
Linha de fomento: Auxílio à Pesquisa - Regular