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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Trials with the Haemonchus vaccine, Barbervax (R), in ewes and lambs in a tropical environment: Nutrient supplementation improves protection in periparturient ewes

Texto completo
Autor(es):
Bassetto, C. C. [1] ; Almeida, F. A. [1] ; Newlands, G. F. J. [2] ; Smith, W. D. [2] ; Castilhos, A. M. [3] ; Fernandes, S. [3] ; Siqueira, E. R. [3] ; Amarante, A. F. T. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista, UNESP, Dept Parasitol, Inst Biociencias, Dist Rubiao Jr S-N, BR-18618689 Botucatu, SP - Brazil
[2] Moredun Res Inst, Pentlands Sci Pk, Edinburgh, Midlothian - Scotland
[3] Univ Estadual Paulista, UNESP, Dept Prod Anim, Fac Med Vet & Zootecnia, Fazenda Expt Lageado, Botucatu, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Veterinary Parasitology; v. 264, p. 52-57, DEC 15 2018.
Citações Web of Science: 2
Resumo

Haemonchus contortus is an economic problem in sheep farms worldwide, mainly in the tropics and subtropics. A vaccine against haemonchosis, called Barbervax (R), was evaluated in ewes under two nutritional status, naturally infected with gastrointestinal nematodes. Ewes were divided into four groups: Supplemented Diet - Vaccine; Supplemented Diet - No vaccine; Basal Diet - Vaccine and Basal Diet - No vaccine. Their lambs were divided in Vaccinated and No vaccine. Ewes were immunised six times starting about 1 month of pregnancy with the first three doses at 3 week intervals and the last three shots at 4 week intervals. Supplemented ewes had higher body weight, body score and packed cell volume compared with those fed a basal diet. Both groups of vaccinated ewes showed a similar response in circulating anti-vaccine antibodies but the vaccine had no discernible effect on either body weight, body score and packed cell volume. There was a marked group difference in the number of ewes that received precautionary treatments with anthelmintic. All 14 Basal Diet - No vaccine ewes required treatment. In contrast only 7 ewes, in the Supplemented Diet - Vaccine group required anthelmintic treatment. In the Basal Diet - Vaccine and in the Supplemented Diet - No Vaccine groups, 12 and 13 ewes needed anthelmintic treatment, respectively. Vaccinated lambs showed much higher antibody titres resulting in 80% less Haemonchus spp. egg counts comparing with no vaccine lambs. Taken together these results clearly suggest that in pregnant and lactating ewes a combined protective effect between vaccination and improved nutrition resulted in fewer precautionary anthelmintic treatments. Thus, it was possible to achieve a more sustainable level of control of the haemonchosis, less dependent on anthelmintic drugs. (AU)

Processo FAPESP: 15/25718-7 - Profilaxia da verminose ovina utilizando o sistema de integração lavoura-pecuária (ILP)
Beneficiário:Fabiana Alves de Almeida
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 15/00221-2 - Vacinação de ovinos contra Haemonchus contortus
Beneficiário:César Cristiano Bassetto
Linha de fomento: Bolsas no Brasil - Pós-Doutorado