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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Stationary RNA polymerase fluctuations during transcription elongation

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Autor(es):
Belitsky, V [1] ; Schuetz, G. M. [2]
Número total de Autores: 2
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Matemat & Estat, Rua Matao 1010, BR-05508090 Sao Paulo, SP - Brazil
[2] Forschungszentrum Julich, Inst Complex Syst 2, Theoret Soft Matter & Biophys, D-52425 Julich - Germany
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Physical Review E; v. 99, n. 1 JAN 7 2019.
Citações Web of Science: 0
Resumo

We study fluctuation effects of nonsteric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track during transcription elongation. Based on a stochastic model that allows for the exact analytical computation of the stationary distribution of RNAPs as a function of their density, interaction strength, nucleoside triphosphate concentration, and rate of pyrophosphate release we predict an almost geometric headway distribution of subsequent RNAP transcribing on the same DNA segment. The localization length which characterizes the decay of the headway distribution depends directly only the average density of RNAP and the interaction strength, but not on specific single-RNAP properties. Density correlations are predicted to decay exponentially with the distance (in units of DNA base pairs), with a correlation length that is significantly shorter than the localization length. (AU)

Processo FAPESP: 17/20696-0 - De sistemas de partículas interagentes a análise topológica de dados
Beneficiário:Vladimir Belitsky
Linha de fomento: Auxílio à Pesquisa - Pesquisador Visitante - Internacional
Processo FAPESP: 17/10555-0 - Modelagem estocástica de sistemas interagentes
Beneficiário:Fabio Prates Machado
Linha de fomento: Auxílio à Pesquisa - Temático