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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Trypanosoma cruzi: analysis of two different strains after piplartine treatment

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Autor(es):
Gabriela Alves Licursi Vieira ; Marco Túlio Alves da Silva ; Luis Octávio Regasini ; Fernando Cotinguiba ; Helen Julie Laure ; José César Rosa ; Maysa Furlan ; Regina Maria Barretto Cicarelli
Número total de Autores: 8
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Infectious Diseases; v. 22, n. 3, p. -, Jun. 2018.
Resumo

ABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effective during the chronic phase. Therefore, it is extremely urgent to find innovative chemotherapeutic agents and/or effective vaccines. Since piplartine has several biological activities, including trypanocidal activity, the present study aimed to evaluate it on two T. cruzi strains proteome. Considerable changes in the expression of some important enzymes involved in parasite protection against oxidative stress, such as tryparedoxin peroxidase (TXNPx) and methionine sulfoxide reductase (MSR) was observed in both strains. These findings suggest that blocking the expression of the two enzymes could be potential targets for therapeutic studies. (AU)

Processo FAPESP: 11/24017-4 - Estudo do metabolismo de selênio em eucariotos primitivos
Beneficiário:Marco Túlio Alves da Silva
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 07/02076-3 - Avaliação da atividade tripanocida de extratos e frações de planta da família Piperaceae
Beneficiário:Regina Maria Barretto Cicarelli
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 07/56140-4 - Estudo do metabolismo de amidas em Piper tuberculatum Jacq. (Piperaceae): aspectos proteômicos e genômicos
Beneficiário:Fernando Cotinguiba da Silva
Linha de fomento: Bolsas no Brasil - Doutorado