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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice

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Autor(es):
M.M. Antunes ; C.B. de Almeida-Souza ; G. Godoy ; A.R. Crisma ; L.N. Masi ; R. Curi ; R.B. Bazotte
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Medical and Biological Research; v. 52, n. 1, p. -, 2019.
Resumo

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes. (AU)

Processo FAPESP: 16/15766-7 - Hipertrofia do músculo esquelético em ratos com Diabetes Mellitus Tipo I
Beneficiário:Rui Curi
Linha de fomento: Auxílio à Pesquisa - Regular