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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives

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Autor(es):
da Graca, Felipe Franco [1, 2] ; Ribeiro de Rezende, Thiago Junqueira [1, 2] ; Rocha Vasconcellos, Luiz Felipe [3] ; Pedroso, Jose Luiz [4] ; Barsottini, Orlando Graziani P. [4] ; Franca, Jr., Marcondes C. [1, 2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Dept Neurol, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Neuroimaging Lab, Campinas, SP - Brazil
[3] Fed Univ Rio De Janeiro UFRJ, Inst Neurol, Rio De Janeiro - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Dept Neurol, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: FRONTIERS IN NEUROLOGY; v. 9, JAN 16 2019.
Citações Web of Science: 1
Resumo

Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts and dorsal columns. Genotypic and phenotypic heterogeneity is a hallmark of this group of diseases, which makes proper diagnosis and management often challenging. In this scenario, magnetic resonance imaging (MRI) emerges as a valuable tool to assist in the exclusion of mimicking disorders and in the detailed phenotypic characterization. Some neuroradiological signs have been reported in specific subtypes of HSP and are therefore helpful to guide genetic testing/interpretation. In addition, advanced MRI techniques enable detection of subtle structural abnormalities not visible on routine scans in the spinal cord and brain of subjects with HSP. In particular, quantitative spinal cord morphometry and diffusion tensor imaging look promising tools to uncover the pathophysiology and to track progression of these diseases. In the current review article, we discuss the current use and future perspectives of MRI in the context of HSP. (AU)

Processo FAPESP: 13/01766-7 - Contribuição ao diagnóstico, à fisiopatologia e à terapêutica das neuronopatias sensitivas
Beneficiário:Marcondes Cavalcante Franca Junior
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores