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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Initial evidence for hypothalamic gliosis in children with obesity by quantitative T2 MRI and implications for blood oxygen-level dependent response to glucose ingestion

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Autor(es):
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Sewaybricker, Leticia E. [1, 2] ; Schur, Ellen A. [1] ; Melhorn, Susan J. [1] ; Campos, Brunno M. [3] ; Askren, Mary K. [4] ; Nogueira, Guilherme A. S. [5] ; Zambon, Mariana P. [2] ; Antonio, Maria Angela R. G. M. [2] ; Cendes, Fernando [3] ; Velloso, Licio A. [5] ; Guerra-Junior, Gil [2]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Washington, Dept Med, Seattle, WA - USA
[2] Univ Estadual Campinas, Sch Med Sci, Dept Pediat, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Campinas, SP - Brazil
[4] Univ Washington, Dept Radiol, Seattle, WA 98195 - USA
[5] Univ Estadual Campinas, Lab Cell Signaling, Dept Internal Med, Campinas, SP - Brazil
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: PEDIATRIC OBESITY; v. 14, n. 2, SI FEB 2019.
Citações Web of Science: 2
Resumo

Objective In adults, hypothalamic gliosis has been documented using quantitative T2 neuroimaging, whereas functional magnetic resonance imaging (fMRI) has shown a defective hypothalamic response to nutrients. No studies have yet evaluated these hypothalamic abnormalities in children with obesity. Methods Children with obesity and lean controls underwent quantitative MRI measuring T2 relaxation time, along with continuous hypothalamic fMRI acquisition to evaluate early response to glucose ingestion. Results Children with obesity (N = 11) had longer T2 relaxation times, consistent with gliosis, in the mediobasal hypothalamus (MBH) compared to controls (N = 9; P = 0.004). Moreover, there was a highly significant group{*}region interaction (P = 0.002), demonstrating that signs of gliosis were specific to MBH and not to reference regions. Longer T2 relaxation times correlated with measures of higher adiposity, including visceral fat percentage (P = 0.01). Mean glucose-induced hypothalamic blood oxygen-level dependent signal change did not differ between groups (P = 0.11). However, mean left MBH T2 relaxation time negatively correlated with glucose-induced hypothalamic signal change (P < 0.05). Conclusion Imaging signs of hypothalamic gliosis were present in children with obesity and positively associated with more severe adiposity. Children with the strongest evidence for gliosis showed the least activation after glucose ingestion. These initial findings suggest that the hypothalamus is both structurally and functionally affected in childhood obesity. (AU)

Processo FAPESP: 09/50809-5 - Inflamação e resposta imune em obesidade
Beneficiário:Licio Augusto Velloso
Linha de fomento: Auxílio à Pesquisa - Temático