Synthesis of Sr-morin complex and its in vitro response: decrease in osteoclast differentiation while sustaining osteoblast mineralization ability

Autor(es)

Cruz, Marcos A. E. ^[1] ; Tovani, Camila B. ^[1] ; Favarin, Bruno Z. ^[1] ; Soares, Mariana P. R. ^[2] ; Fukada, Sandra Y. ^[2] ; Ciancaglini, Pietro ^[1] ; Ramos, Ana P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MATERIALS CHEMISTRY B; v. 7, n. 5, p. 823-829, FEB 7 2019.
• Citações Web of Science: 2

Resumo

Strontium ranelate (SrR) has been used as the ultimate choice for osteoporosis treatment. However, the development of more tolerable and bioactive Sr2+ carriers is still a need. The design of Sr2+-based platforms has moved towards the obtention of anion carriers that can also exhibit a positive effect on bone metabolism. In this sense, we used morin, a natural flavonoid, as a new arrangement for Sr2+ carriage in the synthesis of an Sr2+ complex. It has been claimed that phenolic compounds promote bone health. Therefore, we hypothesized that the association of Sr2+ with morin could improve its anabolic effects. Complexes with the general formula {[}(C15H9O7)Sr(H2O)(2)]Cl center dot 3H(2)O were synthesized and characterized by elemental analysis, thermogravimetry, UV-Vis and infrared absorption spectroscopies and H-1-nuclear magnetic resonance. We showed that the complexation between morin and Sr2+ occurred among the 3-OH and 4C=O groups of morin. Preosteoclasts cultures with the Sr-morin complex exhibited a reduced osteoclast differentiation rate and sustained osteoblast mineralization ability. The response of Sr-morin was higher than that observed for SrR at the same concentration range. Considering the above-mentioned observations, the Sr-morin complex could be an interesting approach to be further exploited not only as an alternative treatment for osteoporosis but also in the design of materials for faster osteointegration. (AU)

• Processo FAPESP: 15/09034-0 - Efeito da O-GlcNacilação sobre a osteoclastogênese e reabsorção óssea
• Beneficiário: Sandra Yasuyo Fukada Alves
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 17/08892-9 - Superfícies bioativas obtidas a partir de filmes Langmuir-Blodgett e biominerais
• Beneficiário: Ana Paula Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/24249-0 - Associação de proteínas osteogênicas a biominerais e óxidos metálicos dopados com terras-raras: interação com sistemas modelo de membrana
• Beneficiário: Camila Bussola Tovani
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/21236-0 - Sistemas miméticos de vesículas da matriz extracellular (MVs) para o estudo da regulação do processo de biomineralização: proteolipossomos contendo NPP1 e Anexina V
• Beneficiário: Pietro Ciancaglini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/08774-0 - Modificação de superfícies de Ti com filmes híbridos Langmuir-Blodgett contendo biominerais e ranelato de estrôncio para liberação controlada de Sr2+
• Beneficiário: Marcos Antonio Eufrásio Cruz
• Modalidade de apoio: Bolsas no Brasil - Mestrado