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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Butyrate Attenuates Lung Inflammation by Negatively Modulating Th9 Cells

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Autor(es):
Vieira, Raquel de Souza [1] ; Castoldi, Angela [1] ; Basso, Paulo Jose [1] ; Hiyane, Meire Ioshie [1] ; Saraiva Camara, Niels Olsen [2, 1, 3] ; Almeida, Rafael Ribeiro [1, 4]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat lmmunobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Nephrol Div, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Clin Med, Renal Pathophysiol Lab, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Lab Immunol, Heart Inst InCor, Sao Paulo - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN IMMUNOLOGY; v. 10, JAN 29 2019.
Citações Web of Science: 3
Resumo

Th9 cells orchestrate allergic lung inflammation by promoting recruitment and activation of eosinophils and mast cells, and by stimulating epithelial mucus production, which is known to be mainly dependent on IL-9. These cells share developmental pathways with induced regulatory T cells that may determine the generation of one over the other subset. In fact, the FOXP3 transcription factor has been shown to bind il9 locus and repress IL-9 production. The microbiota-derived short-chain fatty acids (SCFAs) butyrate and propionate have been described as FOXP3 inducers and are known to have anti-inflammatory properties. While SCFAs attenuate lung inflammation by inducing regulatory T cells and suppressing Th2 responses, their effects on Th9 cells have not been addressed yet. Therefore, we hypothesized that SCFAs would have a protective role in lung inflammation by negatively modulating differentiation and function of Th9 cells. Our results demonstrated that butyrate is more effective than propionate in promoting FOXP3 expression and IL-9 repression. In addition, propionate was found to negatively impact in vitro differentiation of IL-13-expressing T cells. Butyrate treatment attenuated lung inflammation and mucus production in OVA-challenged mice, which presented lower frequency of lung-infiltrated Th9 cells and eosinophils. Both Th9 cell adoptive transfer and IL-9 treatment restored lung inflammation in butyrate-treated OVA-challenged mice, indicating that the anti-inflammatory effects of butyrate may rely on suppressing Th9-mediated immune responses. (AU)

Processo FAPESP: 15/26682-6 - Avaliação do papel de mTOR no metabolismo energético e ativação de células B durante a inflamação intestinal experimental
Beneficiário:Paulo José Basso
Linha de fomento: Bolsas no Brasil - Doutorado
Processo FAPESP: 15/13817-0 - O papel da microbiota no desenvolvimento da atividade antitumoral mediada por células de perfil Th9
Beneficiário:Rafael Ribeiro Almeida
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/03532-1 - Impacto de produtos microbianos na modulação de células t CD8+IL-9+ na inflamação pulmonar experimental
Beneficiário:Raquel de Souza Vieira
Linha de fomento: Bolsas no Brasil - Iniciação Científica