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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Resting heart rate and risk of type 2 diabetes: A prospective cohort study and meta-analysis

Texto completo
Autor(es):
Lee, Dong Hoon [1] ; Machado de Rezende, Leandro Fornias [2] ; Hu, Frank B. [3, 4, 1, 5] ; Jeon, Justin Y. [6, 7] ; Giovannucci, Edward L. [3, 4, 1, 5]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Bldg 2, 3rd Floor, Boston, MA 02115 - USA
[2] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[3] Harvard Med Sch, Boston, MA - USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[5] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
[6] Yonsei Univ, Dept Sport Ind Studies, Exercise Med & Rehabil Lab, Seoul - South Korea
[7] Yonsei Univ, Coll Med, ICONS, Exercise Med Ctr Diabet & Canc Patients, Seoul - South Korea
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: Diabetes/Metabolism Research and Reviews; v. 35, n. 2 FEB 2019.
Citações Web of Science: 2
Resumo

Background Positive association between resting heart rate (RHR) and risk of type 2 diabetes (T2D) has been documented in several studies. However, whether RHR is an independent predictor of T2D and its potential interaction with other risk factors of T2D remain unclear. Methods We conducted a prospective cohort study of 31 156 men from the Health Professionals Follow-up Study (1992-2012). Cox proportional hazard model was used to examine the association between RHR and T2D risk. We further examined whether this association is modified by known risk factors. Lastly, we conducted a meta-analysis of prospective cohort studies. Results During 505 380 person-years of follow-up, we identified 2338 incident T2D cases. The multivariable-adjusted hazard ratio (HR) comparing the highest vs lowest categories of RHR was 1.69 (95% confidence interval {[}CI], 1.43-2.01). Increase in 10 bpm of RHR was associated with 19% increased risk of T2D in the fully adjusted model (HR, 1.19; 95% CI, 1.14-1.24). The HRs of T2D associated with RHR were stronger among those with normal weight or without hypertension (P interaction < 0.001). Moreover, RHR with other known risk factors cumulatively increased T2D risk. A meta-analysis consistently showed a positive association between RHR and T2D risk (the summary relative risk {[}RR] for highest vs lowest RHR, 1.53; 95% CI, 1.26-1.86, n = 12, the summary RR per 10 bpm increase, 1.17; 95% CI, 1.09-1.26, n = 13). Conclusions High RHR was independently associated with increased risk of T2D. Our findings suggest that RHR, with other known risk factors, could be a useful tool to predict T2D risk. (AU)

Processo FAPESP: 16/21390-0 - Carga do câncer atribuível ao estilo de vida no Brasil
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 14/25614-4 - Inatividade física e câncer: da avaliação da evidência etiológica ao impacto na saúde pública
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Brasil - Doutorado