| Texto completo | |
| Autor(es): |
do Amaral Montanheiro, Thais Larissa
[1, 2]
;
Montagna, Larissa Stieven
[2]
;
Patrulea, Viorica
[3]
;
Jordan, Olivier
[3]
;
Borchard, Gerrit
[3]
;
Monteiro Lobato, Gabriela Matheus
[4]
;
Catalani, Luiz Henrique
[4]
;
Lemes, Ana Paula
[2]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Technol Inst Aeronaut, Div Fundamental Sci, Lab Nanotechnol, Praca Marechal Eduardo Gomes, 50 Vila Acacias, BR-12228900 Sao Jose Dos Campos, SP - Brazil
[2] Univ Fed Sao Paulo, Technol Lab Polymers & Biopolymers, 330 Vila Nair, BR-12231280 Sao Jose Dos Campos, SP - Brazil
[3] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1211 Geneva - Switzerland
[4] Univ Sao Paulo, Inst Chem, Lab Polymer Biomat, Ave Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of Materials Science; v. 54, n. 9, p. 7198-7210, MAY 2019. |
| Citações Web of Science: | 2 |
| Resumo | |
Nanocomposite scaffolds of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) with 1, 2 and 3% (wt) of cellulose nanocrystals (CNC) were produced by thermally induced phase separation. CNC presented an average length of 91 +/- 26 nm and average diameter of 7 +/- 1 nm, determined by atomic force microscopy (AFM). Field emission gun scanning electron microscopy (FEG-SEM) and X-ray microtomography showed porous morphology with interconnected pores, porosity between 41 and 77% and micron-sized CNC dispersion along the samples. Pore distribution after introducing CNC was less regular with an average reduction of 37% in the porosity. The compression modulus was improved about 28% for PHBV/1% CNC, 25% for PHBV/2% CNC and 63% for PHBV/3% CNC. Mouse fibroblasts attached and proliferated better on PHBV/CNC scaffolds surface than on neat PHBV or tissue culture plate controls. After 10 days of cell culture, PHBV/2% CNC sample enhanced cell proliferation with 42%, compared to neat PHBV. Therefore, the addition of CNC can improve both compressive modulus and cell proliferation, making the composite scaffold a potential candidate for tissue engineering. (AU) | |
| Processo FAPESP: | 13/27064-9 - Utilização de nanocristais de celulose na produção de nanocompósitos poliméricos para aplicações na área médica |
| Beneficiário: | Ana Paula Lemes |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/21442-6 - Polímeros sintéticos e naturais aplicados à engenharia de tecido |
| Beneficiário: | Luiz Henrique Catalani |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |