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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Ethnopharmacology Study of Plants from Atlantic Forest with Leishmanicidal Activity

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Autor(es):
Santos, Beatriz Mendes [1, 2] ; Bezerra-Souza, Adriana [1] ; Aragaki, Sonia [3] ; Rodrigues, Eliana [4] ; Umehara, Eric [5] ; Ghilardi Lago, Joao Henrique [5] ; Laurenti, Marcia Dalastra [6, 7] ; Ribeiro, Susan Pereira [8] ; Domingues Passero, Luiz Felipe [1, 2]
Número total de Autores: 9
Afiliação do(s) autor(es):
[1] Sao Paulo State Univ UNESP, Inst Biosci, Praca Infante Dom Henrique S-N, BR-11330900 Sao Vicente, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Adv Studies Ocean, Ave Joao Francisco Bensdorp 1178, BR-11350011 Sao Vicente, SP - Brazil
[3] Inst Bot Estado Sao Paulo, Nucleo Pesquisa Curadoria Herbario, Ave Miguel Stefano 3687, BR-04301902 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Ctr Ethnobot & Ethnopharmacol Studies CEE, Sao Paulo - Brazil
[5] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Ave Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[6] Univ Sao Paulo, Sch Med, Lab Pathol Infect Dis, Sao Paulo, SP - Brazil
[7] Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, SP - Brazil
[8] Case Western Reserve Univ, Dept Pathol, 2103 Cornell Rd, Room 5503, Cleveland, OH 44106 - USA
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: Evidence-based Complementary and Alternative Medicine; 2019.
Citações Web of Science: 0
Resumo

Leishmaniasis is an infectious disease caused by a protozoan belonging to Leishmania genus. Different clinical outcomes can be observed depending on the parasite species and patient's health condition. The outcomes can range from single cutaneous lesions to lethal visceral form. The treatment of all forms of leishmaniasis is based on pentavalent antimonials, and, in some cases, the second-line drug, amphotericin B, is used. Beside the toxicity of both classes of drugs, in some areas of the world, parasites are resistant to antimonial. These detrimental features make fundamental the discovery and characterization of new drugs or plant extracts with leishmanicidal effects. Brazil is a well-known country for its biodiversity. Additionally, the common knowledge inherited for generations in small villages makes Brazil a source of new information and resources for the discovery and development of new drugs. Based on ethnopharmacology, elderlies were interviewed about plants they commonly used for skin diseases and infections. Five native plants from Atlantic forest were indicated; EtOH and n-hexane extracts were prepared with the vegetative organs of the plants and assayed against promastigote and amastigote forms of L. (L.) amazonensis. The major molecules of each extract were detected using qualitative nuclear magnetic resonance. Among all tested extracts, the n-hexane extract from the leave of Eugenia uniflora (Myrtaceae), enriched in myricitrin and quercitrin flavonoids, was the most effective against L. (L.) amazonensis amastigotes. This data supports the ethnopharmacology approach as a successful tool for the discovery of new drugs with leishmanicidal effects. (AU)

Processo FAPESP: 18/07885-1 - Biomoléculas oriundas de espécies vegetais de áreas remanescentes da Mata Atlântica e do Cerrado para tratamento de doenças tropicais negligenciadas - aspectos químicos e farmacológicos
Beneficiário:João Henrique Ghilardi Lago
Linha de fomento: Auxílio à Pesquisa - Programa BIOTA - Regular