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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

An Outbreak of Human Parvovirus B19 Hidden by Dengue Fever

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Autor(es):
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Di Paola, Nicholas [1] ; Mesquita, Flavio S. [1] ; Leal de Oliveira, Danielle Bruna [1] ; Villabona-Arenas, Christian Julian [2] ; Pour, Shahab Zaki [1] ; de Sousa-Capra, Carla [3] ; Lopes, Gabriela Pessanha [4] ; Ferraz Santana, Rubia Anita [4] ; Rebello Pinho, Joao Renato [4, 5] ; Balarini, Karime [6] ; Theoto Pereira da Fonseca, Celso Ricardo [6] ; de Andrade Zanotto, Paolo Marinho [1]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Ave Prof Lineu Prestes 1374, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Montpellier, INSERM, Inst Rech Dev, Rech Translat Virus Immunodeficience & Malad Infe, Montpellier - France
[3] Dept Hlth Guaruja, Off Epidemiol Surveillance, Sao Paulo - Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil
[5] Univ Sao Paulo, Fac Med, Lab Gastroenterol Clin & Expt, Lab Med Lab, Sao Paulo - Brazil
[6] Itapema Lab Anal Clin, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Clinical Infectious Diseases; v. 68, n. 5, p. 810-817, MAR 1 2019.
Citações Web of Science: 0
Resumo

Background. Seasonal outbreaks of dengue often result in hundreds of dengue-suspected cases where a clinical diagnosis cannot be confirmed. Usually, during large outbreaks of dengue and other pathogens that can cause acute febrile illnesses, the search for secondary pathogens with similar disease outcomes is rare. Methods. Using total RNA sequencing and targeted diagnostic assays, we discovered an outbreak of parvovirus B19 in dengue-suspected patients that occurred from November 2013 to February 2014. Results. Of the 182 cases investigated, 63% were viremic for the B19 virus. Moreover, we found that >43% of infected patients had no serological evidence of prior infection. Parvovirus B19 is a typical childhood infection, yet we observed that 82% of the infected patients were adults. Additionally, we perceived that infected adults had significantly higher presentations of myalgia than in children. We also obtained viral protein (VP) 1/VP2 gene nucleotide sequences from 43 patients. Conclusions. Our results support the utility of next-generation sequencing for symptomatic patients with unknown etiologies during seasonal outbreaks of dengue and other arborviruses. Our findings could improve the vigilance of hospitals and laboratories by raising awareness of co-circulating pathogens such as parvovirus B19 that may be hidden in plain sight. (AU)

Processo FAPESP: 14/17766-9 - Abordagem sistêmica no estudo da permissividade do Anticarsia gemmatalis múltiplo nucleopoliedrovírus (AgMNPV)
Beneficiário:Paolo Marinho de Andrade Zanotto
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/25643-7 - Caracterização molecular e perfil epidemiológico da infecção por adenovírus humano em pacientes pediátricos com infecção respiratória aguda em São Paulo
Beneficiário:Flávio da Silva Mesquita
Linha de fomento: Bolsas no Brasil - Iniciação Científica
Processo FAPESP: 13/22136-1 - Aplicação de metagenômica para descoberta de novos vírus na Mata Atlântica paulista
Beneficiário:Nicholas Di Paola
Linha de fomento: Bolsas no Brasil - Doutorado Direto