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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Cannabinoid signalling in embryonic and adult neurogenesis: possible implications for psychiatric and neurological disorders

Texto completo
Autor(es):
de Oliveira, Rubia W. [1] ; Oliveira, Cilene L. [2] ; Guimaraes, Francisco S. [3, 4] ; Campos, Alline C. [3, 4]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana - Brazil
[2] Univ Fed Santa Catarina, Dept Physiol Sci, Florianopolis, SC - Brazil
[3] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo de Revisão
Fonte: ACTA NEUROPSYCHIATRICA; v. 31, n. 1, p. 1-16, FEB 2019.
Citações Web of Science: 4
Resumo

Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline. Qualitative evaluation of the selected studies indicated that activation of cannabinoid receptors may change neurogenesis in embryonic or adult nervous systems alongside rescue of phenotypes in animal models of different psychiatric and neurological disorders. The text offers an overview on the effects of cannabinoids on central nervous system development and the possible links with psychiatric and neurological disorders such as anxiety, depression, schizophrenia, brain ischaemia/stroke and Alzheimer's disease. An understanding of the mechanisms by which cannabinoid signalling influences developmental and adult neurogenesis will help foster the development of new therapeutic strategies for neurodevelopmental, psychiatric and neurological disorders. (AU)

Processo FAPESP: 12/17626-7 - Mecanismos celulares e moleculares envolvidos no papel de neurotransmissores atípicos em transtornos neuropsiquiátricos
Beneficiário:Francisco Silveira Guimaraes
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 15/05551-0 - Estudo do papel do sistema endocanabinóide nos efeitos comportamentais e plásticos dos fármacos antidepressivos
Beneficiário:Alline Cristina de Campos
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores