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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Long Sleep Duration, Insomnia, and Insomnia With Short Objective Sleep Duration Are Independently Associated With Short Telomere Length

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Autor(es):
Tempaku, Priscila [1] ; Hirotsu, Camila [1, 2] ; Mazzotti, Diego [3] ; Xavier, Gabriela [4, 5] ; Maurya, Pawan [6, 7] ; Brielzke, Elisa [6] ; Belangero, Sintia [4, 6, 5] ; Poyares, Dalva [1] ; Bittencourt, Lia [1] ; Tufik, Sergio [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Lausanne Univ Hosp, Ctr Invest & Res Sleep, Dept Internal Med, Lausanne - Switzerland
[3] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[4] Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo, LiNC Interdisciplinary Lab Clin Neurosci, Sao Paulo - Brazil
[6] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo - Brazil
[7] Cent Univ Haryana, Dept Biochem, Mahendergarh - India
Número total de Afiliações: 7
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL SLEEP MEDICINE; v. 14, n. 12, p. 2037-2045, 2018.
Citações Web of Science: 2
Resumo

Study Objectives: We aimed to determine the association between short telomere length, sleep parameters, and sleep disorders in an adult general population sample. Methods: As part of the EPISONO cohort (Sao Paulo, Brazil), 925 individuals answered questionnaires, underwent a full-night polysomnography and clinical assessment, and had peripheral blood collected for DNA extraction. Insomnia was diagnosed based on the Diagnostic and Statistical Manual of Mental Disorders, 4th edition; and obstructive sleep apnea was defined according to apnea-hypopnea index. For the objective insomnia phenotype, we combined insomnia diagnosis with total sleep time from polysomnography with a cutoff of 360 minutes, allowing the classification of six groups. Self-reported sleep duration was used to classify the individuals as short (< 6 hours), average (6 to 8 hours) and long (> 8 hours) sleepers. The leukocyte telomere length was measured using quantitative real-time polymerase chain reaction. Based on its distribution, we considered leukocyte telomere length < 10th percentile as short telomere and leukocyte telomere length >= 10th percentile as non-short telomere. Results: After adjusting for sex, age, and body mass index, only insomnia disorder (odds ratio {[}OR] = 2.654, 95% confidence interval {[}CI] = 1.025-6.873, P = .044), insomnia disorder total sleep time < 360 minutes (OR = 4.205, 95% CI = 1.097-16.117, P = .036) and long sleepers (OR = 2.177, 95% CI = 1.1893.987, P = .012) were associated with short telomere. Conclusions: Our findings support the existence of an association among insomnia, insomnia phenotype, and self-reported long sleep duration with the maintenance of telomere length. Commentary: A commentary on this article appears in this issue on page 1975. (AU)

Processo FAPESP: 15/17549-0 - Avaliação objetiva do sono e do comprimento médio dos telômeros em uma amostra da cidade de São Paulo
Beneficiário:Priscila Farias Tempaku
Linha de fomento: Bolsas no Brasil - Mestrado
Processo FAPESP: 14/15259-2 - Epidemiologia do sono na Cidade de São Paulo: seguimento dos voluntários do estudo de base EPISONO
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Pós-Doutorado