The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes

Autor(es):Mostrar menos -

Guilherme, Joao Paulo L. F. ^[1] ; Egorova, Emiliya S. ^[2] ; Semenova, Ekaterina A. ^{[3, 4]} ; Kostryukova, Elena S. ^[3] ; Kulemin, Nickolay A. ^[3] ; Borisov, Oleg V. ^{[5, 3]} ; Khabibova, Sofya A. ^[3] ; Larin, Andrey K. ^[3] ; Ospanova, Elena A. ^[3] ; Pavlenko, Alexander V. ^[3] ; Lyubaeva, Ekaterina V. ^[6] ; Popov, Daniil V. ^[6] ; Lysenko, Evgeny A. ^[6] ; Vepkhvadze, Tatiana F. ^[6] ; Lednev, Egor M. ^[6] ; Govorun, Vadim M. ^[3] ; Generozov, Edward V. ^[3] ; Ahmetov, Ildus I. ^{[7, 2, 3, 8]} ; Lancha, Antonio H. Junior ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Biodynam Human Body Movement, Lab Appl Nutr & Metab, Sao Paulo - Brazil

^[2] Kazan State Med Univ, Lab Mol Genet, Kazan - Russia

^[3] Fed Med Biol Agcy, Dept Mol Biol & Genet, Fed Res & Clin Ctr Phys Chem Med, Moscow - Russia

^[4] Kazan Fed Univ, Dept Biochem, Kazan - Russia

^[5] State Univ, Moscow Inst Phys & Technol, Moscow - Russia

^[6] Russian Acad Sci, Inst Biomed Problems, Lab Exercise Physiol, Moscow - Russia

^[7] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England

^[8] St Petersburg Res Inst Phys Culture, Sports Genet Lab, St Petersburg - Russia

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF STRENGTH AND CONDITIONING RESEARCH; v. 33, n. 3, p. 691-700, MAR 2019.
• Citações Web of Science: 2

Resumo

Guilherme, JPLF, Egorova, ES, Semenova, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Ospanova, EA, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Govorun, VM, Generozov, EV, Ahmetov, II, and Lancha Junior, AH. The A-allele of the FTO gene rs9939609 polymorphism is associated with decreased proportion of slow oxidative muscle fibers and over-represented in heavier athletes. J Strength Cond Res 33(3): 691-700, 2019-The purpose of this study was to explore the frequency of the FTO T > A (rs9939609) polymorphism in elite athletes from 2 cohorts (Brazil and Russia), as well as to find a relationship between FTO genotypes and muscle fiber composition. A total of 677 athletes and 652 nonathletes were evaluated in the Brazilian cohort, whereas a total of 920 athletes and 754 nonathletes were evaluated in the Russian cohort. It was found a trend for a lower frequency of A/A genotype in long-distance athletes compared with nonathletes (odds ratio {[}OR]: 0.65; p = 0.054). By contrast, it was found an increased frequency of the A-allele in Russian power athletes. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a Russian power athlete compared with matched nonathletes (OR: 1.45; p = 0.002). Different from that observed in combat sports athletes of lighter weight categories, the A-allele was also over-represented in combat sports athletes of heavier weight categories. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a combat sports athlete of heavier weight categories compared with nonathletes (OR: 1.79; p = 0.018). Regarding the muscle fibers, we found that carriers of the A/A genotype had less slow-twitch muscle fibers than T-allele carriers (p = 0.029). In conclusion, the A/A genotype of the FTO T > A polymorphism is under-represented in athletes more reliant on a lean phenotype and associated with decreased proportion of slow-twitch muscle fibers, while is over-represented in strength and heavier athletes. (AU)

• Processo FAPESP: 12/22516-6 - Perfil poligênico de atletas brasileiros: distribuição de polimorfismos associados ao desempenho físico
• Beneficiário: João Paulo Limongi França Guilherme
• Modalidade de apoio: Bolsas no Brasil - Doutorado