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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effect of Low-Level Laser Therapy (LLLT) in Pulmonary Inflammation in Asthma Induced by House Dust Mite (HDM): Dosimetry Study

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Autor(es):
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Rigonato-Oliveira, Nicole Cristine [1] ; de Brito, Aurileia Aparecida [1] ; Vitoretti, Luana Beatriz [1] ; Moraes, Gabriel de Cunha [2] ; Goncalves, Tawany [1] ; Herculano, Karine Zanella [1] ; Alves, Cintia Estefano [3] ; Lino-dos-Santos-Franco, Adriana [1] ; Aimbire, Flavio [4] ; Vieira, Rodolfo Paula [5, 6, 7, 8] ; Ligeiro de Oliveira, Ana Paula [1]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Univ Nove Julho UNINOVE, Postgrad Program Biophoton Appl Hlth Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo FMUSP, Med Sch, Heart Inst Clin Hosp, Sao Paulo - Brazil
[3] Univ Nove Julho UNINOVE, Postgrad Publ Heath, Sao Paulo - Brazil
[4] Fed Univ Sao Paulo UNIFESP, Biotechnol & Translat Med, Sao Jose Dos Campos - Brazil
[5] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Rua Pedro Ernesto 240, BR-12245520 Sao Jose Dos Campos, SP - Brazil
[6] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Ave Ana Costa 95, BR-11060001 Santos, SP - Brazil
[7] Univ Brasil, Postgrad Program Bioengn & Biomed Engn, Campus Itaquera, Rua Carolina Fonseca 235, BR-08230030 Sao Paulo, SP - Brazil
[8] Anhembi Morumbi Univ, Sch Med, Ave Deputado Benedito Matarazo 4050, BR-12230002 Sao Jose Dos Campos, SP - Brazil
Número total de Afiliações: 8
Tipo de documento: Artigo Científico
Fonte: INTERNATIONAL JOURNAL OF INFLAMMATION; 2019.
Citações Web of Science: 0
Resumo

Asthma is characterized by chronic inflammation in the airways. Several models have been proposed for the discovery of new therapies. Low-Level Laser Therapy (LLLT) is relatively new and effective, very low cost, with no side effects. However, there is still no consensus on the optimal dose to be used. In this sense, the objective of the present study was to evaluate the best dose in an experimental model of asthma induced by House Dust Mite (HDM). Balb/c mice received administration of 100ug/animal HDM and LLLT applications (diode laser: 660nm, 100mW and four different energies 1J, 3J, 5J, and 7.5J) for 16 days. After 24 hours, we studied inflammatory, functional, and structural parameters. The results showed that LBI was able to modulate the pulmonary inflammation observed by reducing the number of cells in Bronchoalveolar Lavage Fluid (BALF) as well as reducing the percentage of neutrophils, eosinophils and T lymphocytes. On the other hand, LLLT increased the level of IL-10 and reduced levels of IL-4, IL-5 and IL-13 in BALF. LLLT was able to reduce the production of mucus, peribronchial eosinophils, collagen deposition, bronchoconstriction index, and bronchial and muscular thickening in the airways. We concluded that the use of LLLT in the treatment of chronic inflammation of the airways attenuated the inflammatory process and functional and structural parameters. We emphasize, in general, that the 1J and 3J laser presented better results. Thus, photobiomodulation may be considered a promising tool for the treatment of chronic pulmonary allergic inflammation observed in asthma. (AU)

Processo FAPESP: 15/23152-6 - Efeito da terapia com laser de baixa potência (LBP) em modelo experimental de inflamação alérgica pulmonar induzida por house dust mite (HDM): estudo de dosimetria
Beneficiário:Nicole Cristine Rigonato de Oliveira
Linha de fomento: Bolsas no Brasil - Doutorado