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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Fingernail may not be a reliable biomarker of fluoride body burden from dentifrice

Texto completo
Autor(es):
Ynara Bosco Oliveira Lima-Arsati ; Carolina Castro Martins ; Lília Alves Rocha ; Jaime Aparecido Cury
Número total de Autores: 4
Tipo de documento: Artigo Científico
Fonte: Brazilian Dental Journal; v. 21, n. 2, p. -, 2010.
Resumo

Fingernail has been suggested as a biomarker of fluoride (F) body burden, but there is no consensus if it would be a reliable indicator of F exposure from dentifrice. Therefore, the present study was conducted to investigate if fingernails would have sensitivity to detect F exposure from dentifrice in young children. Twenty-three 1-3-year-old children living in the city of Piracicaba (0.72 ppm F in water), Brazil, were enrolled in two phases of different F exposure: in phase A (1st to 11th week), they were exposed to the combination of F from diet (solids and liquids) and dentifrice (1,500 µg F/g as MFP), and in phase B (12th to 29th week), only to F from diet (the use of F dentifrice was interrupted). Fingernails were weekly clipped during 35 weeks for F determination. F intake from diet and dentifrice in each phase was also determined. Both analyses were made with ion-specific electrode. F intake (Mean ± SD) was significantly higher (p<0.01) when the children were exposed to F from diet+dentifrice than only to F from diet (0.086 ± 0.032 and 0.040 ± 0.009 mg F/day/kg body weight, respectively). However, F concentrations in nails collected during the whole experimental period of 35 weeks presented great variation with no trend of decreasing after F dentifrice intake interruption. The findings suggest that fingernail may not be a reliable F biomarker of body burden from dentifrice. (AU)

Processo FAPESP: 99/12239-9 - A unha como indicador biológico de exposição ao flúor para prever risco de fluorose dentária
Beneficiário:Ynara Bosco de Oliveira Lima Arsati
Linha de fomento: Bolsas no Brasil - Doutorado