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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Intracellular Peptides in Cell Biology and Pharmacology

Texto completo
de Araujo, Christiane B. [1] ; Heimann, Andrea S. [2] ; Remer, Ricardo A. [3] ; Russo, Lilian C. [4] ; Colquhoun, Alison [5] ; Forti, Fabio L. [4] ; Ferro, Emer S. [6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Butantan Inst, Special Lab Cell Cycle, Ctr Toxins Immune Response & Cell Signaling CeTIC, BR-05503900 Sao Paulo, SP - Brazil
[2] Proteimax Biotecnol LTDA, BR-05581001 Sao Paulo, SP - Brazil
[3] Remer Consultores Ltda, BR-01411001 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo 1111, Inst Chem, Dept Biochem, BR-05508000 Sao Paulo - Brazil
[5] Univ Sao Paulo, Dept Cell & Dev Biol, BR-05508000 Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: BIOMOLECULES; v. 9, n. 4 APR 2019.
Citações Web of Science: 1

Intracellular peptides are produced by proteasomes following degradation of nuclear, cytosolic, and mitochondrial proteins, and can be further processed by additional peptidases generating a larger pool of peptides within cells. Thousands of intracellular peptides have been sequenced in plants, yeast, zebrafish, rodents, and in human cells and tissues. Relative levels of intracellular peptides undergo changes in human diseases and also when cells are stimulated, corroborating their biological function. However, only a few intracellular peptides have been pharmacologically characterized and their biological significance and mechanism of action remains elusive. Here, some historical and general aspects on intracellular peptides' biology and pharmacology are presented. Hemopressin and Pep19 are examples of intracellular peptides pharmacologically characterized as inverse agonists to cannabinoid type 1 G-protein coupled receptors (CB1R), and hemopressin fragment NFKF is shown herein to attenuate the symptoms of pilocarpine-induced epileptic seizures. Intracellular peptides EL28 (derived from proteasome 26S protease regulatory subunit 4; Rpt2), PepH (derived from Histone H2B type 1-H), and Pep5 (derived from G1/S-specific cyclin D2) are examples of peptides that function intracellularly. Intracellular peptides are suggested as biological functional molecules, and are also promising prototypes for new drug development. (AU)

Processo FAPESP: 16/04000-3 - Farmacologia de oligopeptidases e peptídeos intracelulares
Beneficiário:Emer Suavinho Ferro
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 04/04933-2 - Biologia celular molecular de oligopeptidases
Beneficiário:Emer Suavinho Ferro
Linha de fomento: Auxílio à Pesquisa - Temático