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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Na+/Ca2+ exchangers: Unexploited opportunities for cancer therapy?

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Autor(es):
Rodrigues, Tiago [1, 2] ; Nunez Estevez, Gabriela Nohemi [2] ; dos Santos Tersariol, Ivarne Luis [1, 3]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Mogi Das Cruzes, Interdisciplinary Ctr Biochem Invest CIIB, Mogi Das Cruzes, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[3] Fed Univ Sao Paulo Unifesp Sao Paulo, Sao Paulo Sch Med, Dept Biochem, Sao Paulo, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo de Revisão
Fonte: Biochemical Pharmacology; v. 163, p. 357-361, MAY 2019.
Citações Web of Science: 1
Resumo

Calcium is a well-studied ion that acts as a cofactor in several reactions and as intracellular second messenger. It plays crucial roles in living cells by regulating several processes from cell division to death. The disruption of Ca2+ homeostasis is related to cell and tissue damage and it is involved in several pathological conditions and diseases, including cancer. Tumor cells exhibit several molecular features in relation to normal cells in order to acquire proliferative and survival advantages, and Ca2+ signaling is directly or indirectly involved in these pathways. Thus, changes in the expression of Ca2+ channels and pumps are frequently described in some cancers, including transient receptor potential (TRP) family channels, store- and voltage-gated Ca2+ channels, store release channels, and Ca2+ ATPases. Although the sodium/calcium exchanger (Na+/Ca2+ exchanger; NCX) and the therapeutic potential of its inhibitors have been extensively studied in heart diseases, there are few studies about the molecular and functional aspects of NCX in cancer. Here, the current knowledge about NCX in cancer will be reviewed and possible strategies to target NCX for cancer therapy will be discussed. (AU)

Processo FAPESP: 16/07367-5 - Investigação dos Mecanismos de Indução de Morte Celular por Fenotiazinas em Células Tumorais: Modulação da Expressão Gênica e Papel das Proteínas da Família BCL-2 e Estresse do Retículo Endoplasmático
Beneficiário:Tiago Rodrigues
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 15/03964-6 - Glicosaminoglicanos e proteoglicanos: relação estrutura e função
Beneficiário:Helena Bonciani Nader
Linha de fomento: Auxílio à Pesquisa - Temático