Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Carbon dioxide-catalyzed peroxynitrite reactivity - The resilience of the radical mechanism after two decades of research

Texto completo
Autor(es):
Augusto, Ohara [1] ; Goldstein, Sara [2] ; Hurst, James K. [3] ; Lind, Johan [4] ; Lymar, V, Sergei ; Merenyi, Gabor [4] ; Radi, Rafael [5, 6]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-5508000 Sao Paulo - Brazil
[2] Hebrew Univ Jerusalem, Chem Inst, IL-91904 Jerusalem - Israel
[3] Oregon State Univ, Dept Biochem & Biophys, Corvallis, OR 97331 - USA
[4] Royal Inst Technol, Sch Chem, S-10044 Stockholm - Sweden
[5] Univ Republica, Ctr Free Rad & Biomed Res, Fac Med, Montevideo 11800 - Uruguay
[6] Univ Republica, Dept Bioquim, Fac Med, Montevideo 11800 - Uruguay
Número total de Afiliações: 6
Tipo de documento: Artigo de Revisão
Fonte: Free Radical Biology and Medicine; v. 135, p. 210-215, MAY 1 2019.
Citações Web of Science: 0
Resumo

Peroxynitrite, ONOO-, formed in tissues that are simultaneously generating NO center dot and O-2(center dot-), is widely regarded as a major contributor to oxidative stress. Many of the reactions involved are catalyzed by CO2 via formation of an unstable adduct, ONOOC(O)O-, that undergoes O-O bond homolysis to produce NO2 center dot and CO3 center dot- radicals, whose yields are equal at about 0.33 with respect to the ONOO- reactant. Since its inception two decades ago, this radical-based mechanism has been frequently but unsuccessfully challenged. The most recent among these {[}Serrano-Luginbuehl et al. Chem. Res. Toxicol. 31: 721-730; 2018] claims that ONOOC(O)O- is stable, predicts a yield of NO2 center dot/CO3 center dot- of less than 0.01 under physiological conditions and, contrary to widely accepted viewpoints, suggests that radical generation is inconsequential to peroxynitrite-induced oxidative damage. Here we review the experimental and theoretical evidence that support the radical model and show this recently proposed alternative mechanism to be incorrect. (AU)

Processo FAPESP: 13/07937-8 - Redoxoma
Beneficiário:Ohara Augusto
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs