Association between Insulin-Like Growth Factor-I Levels and the Disease Progression and Anemia in Visceral Leishmaniasis

Autor(es)

de Pinho, Flaviane Alves ^{[1, 2]} ; Vieira Vendrame, Celia Maria ^[1] ; Lima Maciel, Bruna Leal ^[3] ; Silva, Lucilene dos Santos ^[4] ; Miyashiro, Samantha Ive ^[5] ; Bezerra Jeronimo, Selma Maria ^{[6, 7, 8]} ; Goto, Hiro ^{[1, 9]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Sao Paulo - Brazil

^[2] Univ Fed Bahia, Dept Anat Patol & Clin, Escola Med Vet & Zootecnia, Salvador, BA - Brazil

^[3] Univ Fed Rio Grande do Norte, Dept Nutricao, Ctr Ciencias Saude, Natal, RN - Brazil

^[4] Univ Fed Piaui, Setor Patol Anim, Ctr Ciencias Agr, Teresina - Brazil

^[5] Univ Sao Paulo, Dept Clin Med, Fac Med Vet & Zootecnia, Sao Paulo - Brazil

^[6] Univ Fed Rio Grande do Norte, Dept Bioquim, Ctr Biociencias, Natal, RN - Brazil

^[7] Univ Fed Rio Grande do Norte, Inst Trop Med Rio Grande Norte, Natal, RN - Brazil

^[8] Natl Inst Sci & Technol Trop Dis, Natal, RN - Brazil

^[9] Univ Sao Paulo, Dept Med Prevent, Fac Med, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 100, n. 4, p. 808-815, 2019.
• Citações Web of Science: 0

Resumo

We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine production. (AU)

• Processo FAPESP: 10/16257-2 - A patogênese da pancitopenia da leishmaniose visceral canina
• Beneficiário: Flaviane Alves de Pinho
• Modalidade de apoio: Bolsas no Brasil - Doutorado