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Association Between Hematological Parameters and Iron Metabolism Response After Marathon Race and ACTN3 Genotype

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Autor(es):
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Renno Sierra, Ana Paula [1, 2] ; Oliveira, Rodrigo Assuncao [3] ; Silva, Elton Dias [4] ; Oliveira Lima, Giscard Humberto [4, 5] ; Benettil, Marino Pereira [2] ; Pedanti Kiss, Maria Augusta [2] ; Sierra, Carlos Anibal [1] ; Ghorayeb, Nabil [1] ; Seto, Jane T. [6] ; Pesquero, Joao Bosco [4] ; Cury-Boaventura, Maria Fernanda [3]
Número total de Autores: 11
Afiliação do(s) autor(es):
[1] Dante Pazzanese Inst Cardiol, Sports Cardiol Dept, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sports, Dept Biodynam Human Movements, Sao Paulo - Brazil
[3] Cruzeiro do Sul Univ, Dept Interdisciplinary Hlth Sci, Inst Phys Act & Sports Sci, Sao Paulo - Brazil
[4] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[5] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, Program Human Movement & Sport Sci, Rome - Italy
[6] Murdoch Childrens Res Inst, Neuromuscular Res, Melbourne, Vic - Australia
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN PHYSIOLOGY; v. 10, JUN 11 2019.
Citações Web of Science: 0
Resumo

alpha-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, hematological parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated. (AU)

Processo FAPESP: 14/21501-0 - Papel de diferentes genótipos, marcadores de injúria miocárdica e mediadores inflamatórios nas alterações cardiopulmonares induzidas pela maratona
Beneficiário:Maria Fernanda Cury Boaventura
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 14/27198-8 - Estabelecimento de um centro de pesquisa genética e molecular para desafios clínicos
Beneficiário:João Bosco Pesquero
Linha de fomento: Auxílio à Pesquisa - Temático