Short-time high-intensity exercise increases peripheral BDNF in a physical fitness-dependent way in healthy men

Autor(es)

Antunes, Barbara Moura ^[1] ; Rossi, Fabricio Eduardo ^{[2, 3]} ; Teixeira, Ana Maria ^[4] ; Lira, Fabio Santos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Dept Phys Educ, Postgrad Program Movement Sci, Exercise & Immunometab Res Grp, Presidente Prudente, SP - Brazil

^[2] Univ Fed Piaui, Dept Phys Educ, Immunometab Skeletal Muscle & Exercise Res Grp, Teresina - Brazil

^[3] Fed Univ Piaui UFPI, Associate Grad Program Hlth Sci, Teresina Pi - Italy

^[4] Univ Coimbra, Fac Sport Sci & Phys Educ, Res Ctr Sport & Phys Act UID PTD 04213 2016, Coimbra - Portugal

• Tipo de documento: Artigo Científico
• Fonte: European Journal of Sport Science; v. 20, n. 1 MAY 2019.
• Citações Web of Science: 1

Resumo

BDNF is associated with brain health and positively modulated by exercise; however, the influence of physical fitness status on BDNF is incipient. This study investigated the BDNF response after acute-exercise sessions performed at low, moderate, and high intensities and the relationship between physical fitness status and BDNF response. Twenty-eight men, divided according to physical fitness status (50th percentile for VO2max), performed three randomised acute exercise sessions at low (90% of VT1), moderate (midpoint between VT1-VT2), and high (midpoint between VT2-W-max) intensities until exhaustion or for up to 60 min. Lactate and BDNF were determined pre and post-exercises. For BDNF, there were main effects of time (p = 0.003) and interaction (p < 0.001), showing an increase post high-intensity exercise (p < 0.001). Changes in BDNF presented differences between conditions (p < 0.001) with greater increase in high-intensity compared with the others (p = 0.003). For lactate, there were main effects of time (p < 0.001), condition (p < 0.001), and interaction (p < 0.001) with greater concentration in high-intensity. High-intensity exercise exhibited inverse correlation between the changes in BDNF and lactate (r=-0.38, p = 0.044). There was significant correlation between BDNF and VO2max for moderate (r = -0.57, p = 0.002) and a trend for high-intensity condition (r = -0.37, p = 0.050) and when evaluating BDNF according to physical fitness level, it was observed that subjects with lower physical fitness levels had greater increases in BDNF in short-time high-intensity exercise (p = 0.041). In conclusion, short-time high-intensity exercise seems to be more efficient in increasing BDNF concentration, and physical fitness level influences this response, as healthy individuals with lower physical fitness levels were more responsive. (AU)

• Processo FAPESP: 14/08003-1 - Envolvimento do NF-kB e PPAR-gamma na resposta inflamatória e metabólica em monócitos de indivíduos sedentários, fisicamente ativos e treinados
• Beneficiário: Barbara de Moura Mello Antunes
• Modalidade de apoio: Bolsas no Brasil - Doutorado