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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Autonomic dysfunction is frequent and disabling in non-paraneoplastic sensory neuronopathies

Texto completo
Autor(es):
Muro Martinez, Alberto Rolim [1] ; Martins, Melina Pazian [1] ; Ribeiro de Rezende, Thiago Junqueira [1] ; Faber, Ingrid [1] ; Gonzalez Salazar, Carelis del Valle [1] ; Girotto Takazaki, Karen Antonia [1] ; Nucci, Anamarli [1] ; Franca, Jr., Marcondes Cavalcante [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Campinas UNICAMP, Neuromuscular Div, Neurol Dept, Campinas, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 402, p. 111-117, JUL 15 2019.
Citações Web of Science: 0
Resumo

Introduction: Sensory neuronopathies (SN) are characterized by asymmetric non-length dependent sensory deficits and sensory ataxia. Autonomic dysfunction in SN was not yet evaluated regarding its frequency, characteristics and relationship to sensory deficits. To address these issues, we performed a comprehensive clinical and neurophysiological evaluation of a large cohort of patients with non-paraneoplastic SN (np-SN). Methods: We enrolled 50 consecutive patients with npSN and 32 age/sex-matched healthy controls. They were clinically evaluated (SCOPA-Aut scale) and underwent neurophysiological autonomic assessment (quantitative sudomotor axon reflex test, heart rate variability and sympathetic skin response). Results: Mean age of patients was 50.9 +/- 10.3 years and there were 18 men. npSN patients had higher SCOPA-Aut scores than controls (26.63 +/- 12.72 vs. 12.66 +/- 9.11, p < .001). QSART was abnormal in 92% of the patients - sweat volumes in all examined sites were smaller among patients (p < .001). Cardiovascular autonomic neuropathy was more frequent in these patients as well (p < .001). Conclusion: Altogether our results suggest that autonomic dysfunction in distinct domains is frequent in npSN patients. These findings suggest that the clinical picture of npSN is related to a double neuronopathy: sensory and autonomic. (AU)

Processo FAPESP: 13/26410-0 - Estudo clínico, imunológico e neurofisiológico nas neuronopatias sensitivas
Beneficiário:Alberto Rolim Muro Martinez
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 13/01766-7 - Contribuição ao diagnóstico, à fisiopatologia e à terapêutica das neuronopatias sensitivas
Beneficiário:Marcondes Cavalcante Franca Junior
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores