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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Physical activity during adolescence and risk of colorectal adenoma later in life: results from the Nurses' Health Study II

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Autor(es):
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Machado de Rezende, Leandro Fornias [1, 2] ; Lee, Dong Hoon [2] ; Keum, NaNa [2, 3] ; Nimptsch, Katharina [2, 4] ; Song, Mingyang [5, 6, 7, 8, 2] ; Lee, I-Min [5, 9] ; Eluf-Neto, Jose [1] ; Ogino, Shuji [10, 5, 6, 11] ; Fuchs, Charles [12, 13, 14] ; Meyerhardt, Jeffrey [15] ; Chan, Andrew T. [10, 6, 16, 7, 8, 17] ; Willett, Walter [5, 6, 16, 2] ; Giovannucci, Edward [5, 6, 16, 2] ; Wu, Kana [2]
Número total de Autores: 14
Afiliação do(s) autor(es):
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[1] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA
[3] Dongguk Univ, Dept Food Sci & Biotechnol, Goyang - South Korea
[4] Max Delbruck Ctr Mol Med MDC, Mol Epidemiol Res Grp, Berlin - Germany
[5] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[6] Harvard Med Sch, Boston, MA 02115 - USA
[7] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 - USA
[8] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 - USA
[9] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 - USA
[10] Broad Inst MIT & Harvard, Cambridge, MA 02142 - USA
[11] Brigham & Womens Hosp, Dept Pathol, Program MPE Mol Pathol Epidemiol, 75 Francis St, Boston, MA 02115 - USA
[12] Yale Canc Ctr, New Haven, CT - USA
[13] Yale Sch Med, Dept Med, New Haven, CT - USA
[14] Smilow Canc Hosp, New Haven, CT - USA
[15] Dana Faber Canc Inst, Boston, MA - USA
[16] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
[17] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA - USA
Número total de Afiliações: 17
Tipo de documento: Artigo Científico
Fonte: BRITISH JOURNAL OF CANCER; v. 121, n. 1, p. 86-94, JUL 2 2019.
Citações Web of Science: 0
Resumo

BACKGROUND: Physical activity during adulthood has been consistently associated with lower risk of colorectal cancers, but whether physical activity during adolescence may also play a role in colorectal carcinogenesis is unclear. METHODS: We included 28,250 women in the Nurses' Health Study II who provided data on physical activity during adolescence (ages 12-22 years) in 1997 and underwent lower bowel endoscopy (1998-2011). We used logistic regression models for clustered data to examine the association between physical activity during adolescence and risk of adenoma later in life. RESULTS: Physical activity during adolescence was inversely associated with risk of colorectal adenoma (2373 cases), independent of physical activity during adulthood. The multivariable-adjusted odds ratio (OR) of adenoma was 0.89 (95% CI 0.77-1.02; P-trend = 0.03) comparing women with >= 72 metabolic equivalent of tasks-hours/week (MET-h/week) to < 21 MET-h/week. Women with high physical activity during both adolescence (>= 53.3 MET-h/week) and adulthood (>= 23.1 MET-h/week) had significantly lower risk of adenoma (all adenomas: OR 0.76; 95% CI 0.66-0.88; advanced adenoma: OR 0.61; 95% CI 0.45-0.82) compared to women with low physical activity during both stages of life. CONCLUSIONS: Our findings suggest that physical activity during adolescence may lower the risk of colorectal adenoma later in life. (AU)

Processo FAPESP: 16/21390-0 - Carga do câncer atribuível ao estilo de vida no Brasil
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
Processo FAPESP: 14/25614-4 - Inatividade física e câncer: da avaliação da evidência etiológica ao impacto na saúde pública
Beneficiário:Leandro Fórnias Machado de Rezende
Linha de fomento: Bolsas no Brasil - Doutorado