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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Evaluation of the sequence method as a tool to assess spontaneous baroreflex in reptiles

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Autor(es):
Filogonio, Renato [1] ; Orsolini, Karina F. [1] ; Castro, Samanta A. [1] ; Oda, Gustavo M. [1] ; Rocha, Gabriella C. [1] ; Tavares, Driele [1] ; Abe, Augusto S. [2] ; Leite, Cleo A. C. [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Fed Univ Sao Carlos UFSCar, Dept Physiol Sci, Washington Luiz HWY Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] State Univ Sao Paulo UNESP, Dept Zool, Rio Claro, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY; v. 331, n. 7, p. 374-381, AUG 2019.
Citações Web of Science: 0
Resumo

The sequence method is an alternative to the traditional pharmacological approach (i.e., the Oxford technique) used to calculate baroreflex gain (G) in mammals. Although the sequence method assesses baroreflex by measuring spontaneous events of blood pressure regulation, the pharmacological method relies on the injection of vasoactive drugs that impact the baroreflex mechanism itself. The sequence method might be relevant for dynamic measurement of baroreflex modulation but it was never validated for vertebrates with low heart rate. Hence, we tested the sequence method in three species of reptiles and compared the results with those provided by the classic pharmacological method. G was similar between both methods and values correlated when parameters for the sequence method were set at delay 0 or 1 (i.e., the baroreflex system responds immediately to blood pressure changes or after 1 heartbeat). Calculation of the baroreflex effectiveness index was adequate at a minimum of 300 cycles and a delay of 1 for the three species. Therefore, the sequence method has been validated to investigate baroreflex regulation in reptiles, enabling studies during dynamic alterations in homeostasis. (AU)

Processo FAPESP: 18/05035-0 - Ajustes cardiovasculares em Squamata: validação do modelo da cascavel descerebrada para estudos de mecanismos regulatórios cardiovasculares
Beneficiário:Cléo Alcantara Costa Leite
Linha de fomento: Auxílio à Pesquisa - Regular