Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Systemic administration of curcumin or piperine enhances the periodontal repair: a preliminary study in rats

Texto completo
Autor(es):
Guimaraes-Stabili, Morgana R. [1] ; de Aquino, Sabrina Garcia [2] ; Curylofo, Fabiana de Almeida [1] ; Tasso, Camilla Olga [1] ; Godoy Rocha, Fernanda Regina [1] ; de Medeiros, Marcell Costa [1] ; de Pizzo Jr, Jose Paulo ; Cerri, Paulo Sergio [3] ; Romito, Giuseppe Alexandre [4] ; Rossa Jr, Carlos
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Araraquara Univ Estadual Paulista UNESP, Sch Dent, Dept Diag & Surg, Rua Humaita, 1680 Ctr, BR-14801903 Araraquara, SP - Brazil
[2] Univ Fed Paraiba, Dept Clin & Social Dent, Hlth Sci Ctr, Joao Pessoa, Paraiba - Brazil
[3] de Pizzo Jr, Jr., Jose Paulo, UNESP, Sch Dent Araraquara, Dept Histol & Embriol, Araraquara, SP - Brazil
[4] Univ Sao Paulo, Dept Stomatol, Sch Dent, Sao Paulo, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: CLINICAL ORAL INVESTIGATIONS; v. 23, n. 8, p. 3297-3306, AUG 2019.
Citações Web of Science: 2
Resumo

ObjectivesStudies have documented the anti-inflammatory effects of spices, which may be related to treatment of chronic diseases. The purpose of this study was to evaluate the influence of curcumin and piperine and their association on experimental periodontal repair in rats.Materials and methodsPeriodontitis was induced via the installation of a ligature around the first molar. After 15days, the ligatures were removed, and the rats were separated into groups (12 animals per group): (i) curcumin, (ii) piperine, (iii) curcumin+piperine, (iv) corn oil vehicle, and (v) control group (animals had ligature-induced periodontitis but were not treated). The compounds were administered daily, for 15days by oral gavage. Animals were euthanized at 5 and 15days, and hemimaxillae and gingival tissues were harvested. Bone repair was assessed by mu CT (microcomputer tomography). Histological sections were stained with hematoxylin/eosin (H/E) for the assessment of cellular infiltrate or picrosirius red for quantification of collagen content, and subjected to immunohistochemistry for detecting NF-?B. Gingival tissues were used to evaluate levels of TGF-beta and IL-10 (ELISA).ResultsCurcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-?B in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.ConclusionCurcumin and piperine promoted a substantive effect on tissue repair; however, there was not synergistic effect of compounds administered in combination.Clinical relevanceCurcumin and piperine stimulates the tissue repair and may be potential candidates for the treatment of periodontal disease. (AU)

Processo FAPESP: 10/19660-2 - Mecanismos biológicos da modulação de osteoclastogênese, reabsorção e reparo ósseo mediados por curcumin
Beneficiário:Morgana Rodrigues Guimarães Stabili
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 10/20091-2 - Mecanismos biológicos da modulação de osteoclastogênese, reabsorção e reparo ósseo mediados por curcumin
Beneficiário:Carlos Rossa Junior
Linha de fomento: Auxílio à Pesquisa - Regular