Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

L-Arginine supplementation blunts resistance exercise improvement in rats with chronic kidney disease

Texto completo
Autor(es):
Mostrar menos -
Souza, Michel Kendy [1] ; Moraes, Milton Rocha [2, 1] ; Rosa, Thiago Santos [2, 3] ; Passos, Clevia Santos [1] ; Passos Neves, Rodrigo Vanerson [2, 3] ; Haro, Anderson Sola [1] ; Cenedeze, Marcos Antonio [1] ; Alarcon Arias, Simone Costa [4] ; Fujihara, Clarice Kazue [4] ; Teixeira, Simone Aparecida [5] ; Muscara, Marcelo Nicolas [5] ; Saraiva Camara, Niels Olsen [6, 1] ; Pacheco e Silva Filho, Alvaro [1]
Número total de Autores: 13
Afiliação do(s) autor(es):
[1] Fed Univ Sao Paulo UNIFESP, Dept Med, Div Nephrol, Sao Paulo - Brazil
[2] Catholic Univ Brasilia UCB, Grad Program Phys Educ, Brasilia, DF - Brazil
[3] Fed Univ Sao Paulo UNIFESP, Dept Med, Postgrad Program Translat Med, Sao Paulo - Brazil
[4] Univ Sao Paulo FMUSP, Fac Med, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: Life Sciences; v. 232, SEP 1 2019.
Citações Web of Science: 0
Resumo

Chronic kidney disease (CKD) patients present L-arginine (L-arg) deficiency and L-arg supplementation has been used as a treatment. In addition, sarcopenia is another common problem in CKD population, resistance training (RT) is one of the conservative strategies developed to prevent CKD progression, and however there are no evidences of a combination of these two strategies to treat CKD outcomes. The aim of this study was to evaluate the effects of oral L-arg supplementation combined with RT in an experimental model of CKD. Twenty-five Munich-Wistar male rats, 8-week-old were divided in 5 groups: Sham (sedentary control), Nx (CKD sedentary), Nx L-arg (CKD sedentary supplemented with 2% of L-arg), Nx RT (CKD exercised) Nx RT + L-arg (CKD exercised and supplemented with 2% of L-arg). CKD model was obtained by a subtotal 5/6 nephrectomy. RT was performed on a ladder climbing, three weekly sessions on non-consecutive days, with an intensity of 70% maximum carrying capacity. They were submitted to RT and/or L-arg supplementation for 10 weeks. There was a significant improvement in muscle strength, renal function, anti-inflammatory cytokines, arginase metabolism and renal fibrosis after RT. However, the combination of RT and L-arg impaired all the improvements promoted by RT alone. The L-arg supplementation alone did not impair renal fibrosis and renal function. In conclusion, RT improved inflammatory balance, muscle strength, renal function and consequently decreased renal fibrosis. Nevertheless, the association with L-arg supplementation prevented all these effects promoted by RT. (AU)

Processo FAPESP: 17/05264-7 - Metabolismo celular, microbiota e sistema imune: novos paradigmas na fisiopatologia das doenças renais
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
Beneficiário:Niels Olsen Saraiva Câmara
Linha de fomento: Auxílio à Pesquisa - Temático