Haematological and biochemical analysis of healthy neonatal puppies during the immediate foetal-to-neonatal transition

Autor(es)

Lucio, Cristina Fatima ^[1] ; Garcia Silva, Liege Cristina ^[1] ; Vannucchi, Camila Infantosi ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod, Rua Prof Orlando Marques Paiva, 87 Cidade Univ, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTION IN DOMESTIC ANIMALS; v. 54, n. 10 AUG 2019.
• Citações Web of Science: 0

Resumo

For the neonatal patient, precocity of diagnosis is crucial for effectiveness of medical approach. However, the newborn has its own physiological peculiarities due to ongoing adaptive mechanism for extrauterine life and deserves special attention in order to underline a specific management or clinical approach. The objective of this work was to verify clinical adaptations and biochemical balance of neonates during immediate period, with special reference to haematological, renal and metabolic functions. Neonatal puppies (n = 51) were physically examined for vitality and rectal temperature at birth, 5 and 60 min post-birth. Blood was collected at birth and 60 min post-birth for analysis of glucose, sodium, potassium, chlorine, blood urea nitrogen (BUN), haematocrit and haemoglobin. Neonatal vitality was lower at birth compared with 5 min and 60 min post-birth. Progressive decline in rectal temperature (36.5 +/- 0.3 degrees C, 34.2 +/- 0.2 degrees C, 32.3 +/- 0.5 degrees C) was observed at birth, 5 min and 60 min post-birth, respectively. Puppies presented slight hyponatremia (140.7 +/- 0.5 mmol/L) at birth and hypopotassemia (3.5 +/- 0.1 mmol/L) and blood urea nitrogen (13.1 +/- 0.7 mg/dl) during the first hour, and high haematocrit (45.1 +/- 1.0%) and haemoglobin (15.3 +/- 0.3 g/dl) concentration. In conclusion, puppies had rapid evolution of vitality. Marked decrease in rectal temperature occurred at 5 min post-birth. Haematological values of neonates immediately after birth reflected mainly the dam's blood status, not being useful for a blood panel at this time point. The peculiar pattern of BUN, sodium and potassium observed during transition period, suggested that specific reference range should be considered for neonatal puppies. (AU)

• Processo FAPESP: 06/50485-7 - Avaliação bioquímica, hemogasométrica e de estresse intra-parto em neonatos nascidos sob diferentes condições obstétricas como forma de controle da sobrevivência neonatal nas espécies canina e bovina
• Beneficiário: Camila Infantosi Vannucchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 05/57301-6 - Influência das condições obstétricas ao nascimento sobre padrões de vitalidade e bioquímica na espécie canina
• Beneficiário: Cristina de Fátima Lúcio
• Modalidade de apoio: Bolsas no Brasil - Mestrado