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Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil

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Audrey Cilli ; Adriana Luchs ; Elcio Leal ; Danielle Gill ; Flavio Augusto de Pádua Milagres ; Shirley Vasconcelos Komninakis ; Rafael Brustulin ; Maria da Aparecida Rodrigues Teles ; Márcia Cristina Alves Brito Sayão Lobato ; Rogério Togisaki das Chagas ; Maria de Fátima Neves dos Santos Abrão ; Cassia Vitória de Deus Alves Soares ; Xutao Deng ; Eric Delwart ; Ester Cerdeira Sabino ; Antonio Charlys da Costa
Número total de Autores: 16
Tipo de documento: Artigo Científico
Fonte: Memórias do Instituto Oswaldo Cruz; v. 114, p. -, 2019.
Resumo

Human sapoviruses (HSaV) are considered important causative agents of acute gastroenteritis in humans worldwide. However, knowledge of the genetic characteristics of the whole genome of HSaV in Brazil is limited. Here we report the complete genome sequences of six HSaVs GI.2 and two GI.3 strains obtained from children with acute gastroenteritis in the Northern region of Brazil. Next generation sequencing was used to obtain the full genome and molecular characterization of the genome was performed. Phylogenetic analysis of the genome was also performed. Only one complete HSaV GI.2 genome characterization in the country precedes that of the present study. This is the first complete genome sequence of genotype GI.3 in Brazil. The data obtained in this investigation can contribute to the augmentation of the database on the molecular diversity of HSaVs strains circulating in Brazil, and to the improvement of current typing protocols. (AU)