Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Autor(es)

da Cunha, Bianca Rodrigues ^{[1, 2]} ; Domingos, Celia ^{[3, 4]} ; Buzzo Stefanini, Ana Carolina ^{[1, 2]} ; Henrique, Tiago ^[2] ; Polachini, Giovana Mussi ^[2] ; Castelo-Branco, Pedro ^{[3, 4, 5]} ; Tajara, Eloiza Helena ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil

^[2] Sch Med Sao Jose do Rio Preto FAMERP, Dept Mol Biol, Av Brig Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Algarve, Dept Biomed Sci & Med, Faro - Portugal

^[4] Univ Algarve, Ctr Biomed Res CBMR, Faro - Portugal

^[5] Algarve Biomed Ctr, Faro - Portugal

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF CANCER; v. 10, n. 19, p. 4574-4587, 2019.
• Citações Web of Science: 0

Resumo

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses. (AU)

• Processo FAPESP: 13/03839-1 - Estudo das interações entre células de carcinoma de cabeça e pescoço e seu microambiente
• Beneficiário: Eloiza Helena Tajara da Silva
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/06048-2 - Análise do secretoma de carcinoma de cabeça e pescoço e de seu efeito no microambiente tumoral
• Beneficiário: Bianca Rodrigues da Cunha
• Linha de fomento: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/51168-0 - Fatores ambientais, clínicos, histopatológicos e moleculares associados ao desenvolvimento e ao prognóstico de carcinomas epidermoides de cabeça e pescoço
• Beneficiário: Eloiza Helena Tajara da Silva
• Linha de fomento: Auxílio à Pesquisa - Temático