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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Experimental Measurements of the [CO2 (1) + Acetone (2) + Ivermectin (3)] System at High Pressure

Texto completo
Autor(es):
Valarini Junior, Osvaldo [1, 2] ; Ferreira-Pinto, Leandro [3] ; Cabral, Vladimir Ferreira [1] ; Giufrida, Willyan Machado [1, 2] ; Cardozo-Filho, Lucio [1, 4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Maringa, Dept Chem Engn, BR-87020900 Maringa, PR - Brazil
[2] Fac Engn & Arquitetura FEITEP, BR-87070130 Maringa, PR - Brazil
[3] Sao Paulo State Univ UNESP, Dept Energy Engn, BR-01049010 Rosana, SP - Brazil
[4] Ctr Univ Fundacao Ensino Octavio Bastos UNIFEOB, Res Ctr, BR-13874149 Sao Joao Da Boa Vista, SP - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CHEMICAL AND ENGINEERING DATA; v. 64, n. 9, p. 3786-3792, SEP 2019.
Citações Web of Science: 0
Resumo

For potential application to the controlled release of ivermectin from nanoparticle preparations, this study discloses experimental data on the phase transitions in the CO2, acetone, and ivermectin system subjected to high pressures. The data were acquired via the static synthetic method with a variable-volume view cell in the temperature range of 303.15-333.15 K at pressures up to 10 MPa using three concentrations of ivermectin Bla in acetone (0.029, 0.043, and 0.058 mol.kg(-1)) and CO2 molar fractions of 0.3-0.9. Vapor-liquid-type phase transitions were observed, characterized as bubbles in the presence or absence of a solid phase. A solid phase was formed for all ivermectin Bla concentrations evaluated in this study. Determination of the region of precipitation of ivermectin is important for identifying the concentration of the acetone/ivermectin mixture where CO2 will act strongly as an antisolvent. Thermodynamic modeling was performed by considering the system as pseudo-ternary based on the low concentration of ivermectin Bla in the system. Thermodynamics modeling using the Peng(-) Robinson cubic state equation with the van der Waals mixing rule (PR-vdW2) adequately described the experimentally observed trends. (AU)

Processo FAPESP: 18/23063-1 - Estudo do equilíbrio de fases e cinético utilizando CO2 supercrítico da extração de óleos essenciais de matrizes vegetais com potenciais ansiolíticos da região do Paranapanema
Beneficiário:Leandro Ferreira Pinto
Linha de fomento: Auxílio à Pesquisa - Regular