A brief review on the strategy of developing SPR-based biosensors for application to the diagnosis of neglected tropical diseases

Autor(es)

Souto, Denio E. P. ^[1] ; Volpe, Jaqueline ^[1] ; Goncalves, Conrado de C. ^[2] ; Ramos, I, Carlos H. ; Kubota, Lauro T. ^{[3, 4]}

Afiliação do(s) autor(es)

^[1] Fed Univ Parana UPPE, Dept Chem, BR-81530900 Curitiba, Parana - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[3] Ramos, Carlos H., I, Univ Estadual Campinas, UNICAMP, Inst Chem, BR-13083970 Campinas, SP - Brazil

^[4] Natl Inst Sci & Technol Bioanalyt INCTBio, Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Talanta; v. 205, DEC 1 2019.
• Citações Web of Science: 1

Resumo

The phenomenon of surface plasmon resonance (SPR) through optical sensors was developed from initial studies involving excitation of surface plasmons on metallic substrates. From the beginning, these optical systems have attracted increasing interest for application in different areas, ranging from physics, chemistry, and materials science to biology. Although numerous applications have been explored, the use of SPR in the development of biosensors is by far the most prominent. This review provides a brief account of fundamental aspects related to the recent applications of SPR as a tool for the development of new clinical diagnosis methods. The applications of SPR biosensors were illustrated through recent studies published in the field of neglected tropical diseases, with an emphasis on the contributions achieved in visceral leishmaniasis. It was possible to demonstrate the real benefits and the difficulties that the SPR biosensors have encountered in this important and complex system. Finally, future trends in the use of nanomaterials for the development of SPR-based portable devices for application to neglected tropical diseases have been demonstrated. (AU)

• Processo FAPESP: 17/26131-5 - Chaperoma: estudo da relação entre a estrutura dos seus componentes e a manutenção da proteostase
• Beneficiário: Carlos Henrique Inacio Ramos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/26058-6 - Caracterização de interações no sistema de qualidade protéico para a compreensão do seu papel na manutenção da proteostase
• Beneficiário: Dênio Emanuel Pires Souto
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/22127-2 - Desenvolvimento de novos materiais estratégicos para dispositivos analíticos integrados
• Beneficiário: Lauro Tatsuo Kubota
• Modalidade de apoio: Auxílio à Pesquisa - Temático