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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The molecular clock in the skin, its functionality, and how it is disrupted in cutaneous melanoma: a new pharmacological target?

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Autor(es):
Monteiro de Assis, Leonardo Vinicius [1] ; Moraes, Maria Nathalia [1, 2] ; de Lauro Castrucci, Ana Maria [1]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biosci, Dept Physiol, Lab Comparat Physiol Pigmentat, Trav 14, 101, BR-05508090 Sao Paulo - Brazil
[2] Univ Anhembi Morumbi, Sch Hlth Sci, Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: CELLULAR AND MOLECULAR LIFE SCIENCES; v. 76, n. 19, p. 3801-3826, OCT 2019.
Citações Web of Science: 0
Resumo

The skin is the interface between the organism and the external environment, acting as its first barrier. Thus, this organ is constantly challenged by physical stimuli such as UV and infrared radiation, visible light, and temperature as well as chemicals and pathogens. To counteract the deleterious effects of the above-mentioned stimuli, the skin has complex defense mechanisms such as: immune and neuroendocrine systems; shedding of epidermal squamous layers and apoptosis of damaged cells; DNA repair; and pigmentary system. Here we have reviewed the current knowledge regarding which stimuli affect the molecular clock of the skin, the consequences to skin-related biological processes and, based on such knowledge, we suggest some therapeutic targets. We also explored the recent advances regarding the molecular clock disruption in melanoma, its impact on the carcinogenic process, and its therapeutic value in melanoma treatment. (AU)

Processo FAPESP: 12/50214-4 - Mecanismos de ajuste do relógio por luz e temperatura: aspectos filogenéticos
Beneficiário:Ana Maria de Lauro Castrucci
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 18/14728-0 - Melanopsina como fotorreceptor de UVA e sua relação com pigmentação, reparo de DNA, relógio biológico e componentes do eixo HPA: um novo alvo farmacológico?
Beneficiário:Ana Maria de Lauro Castrucci
Modalidade de apoio: Auxílio à Pesquisa - Regular