Inflammation markers in the saliva of infants born from Zika-infected mothers: exploring potential mechanisms of microcephaly during fetal development

Autor(es):Mostrar menos -

de Oliveira, Diogo N. ^[1] ; Lima, Estela O. ^[1] ; Melo, Carlos F. O. R. ^[1] ; Delafiori, Jeany ^[1] ; Guerreiro, Tatiane M. ^[1] ; Rodrigues, Rafael G. M. ^[1] ; Morishita, Karen N. ^[1] ; Silveira, Cynthia ^[2] ; Muraro, Stefanie Primon ^[3] ; de Souza, Gabriela Fabiano ^[3] ; Vieira, Aline ^[3] ; Silva, Antonio ^[4] ; Batista, Rosangela F. ^[4] ; Doriqui, Maria J. R. ^[4] ; Sousa, Patricia S. ^[4] ; Milanez, Guilherme P. ^[3] ; Proenca-Modena, Jose L. ^[3] ; Cavalcanti, Denise P. ^[2] ; Catharino, Rodrigo R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Pharmaceut Sci, INNOVARE Biomarkers Lab, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Med Sci, Med Genet Dept, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Biol Inst, Dept Genet Evolut Microbiol & Immunol, Emerging Viruses Study Lab, Campinas, SP - Brazil

^[4] Univ Fed Maranhao, Publ Hlth Dept, Sao Luis - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 9, SEP 20 2019.
• Citações Web of Science: 0

Resumo

Zika virus (ZIKV) has emerged as one of the most medically relevant viral infections of the past decades; the devastating effects of this virus over the developing brain are a major matter of concern during pregnancy. Although the connection with congenital malformations are well documented, the mechanisms by which ZIKV reach the central nervous system (CNS) and the causes of impaired cortical growth in affected fetuses need to be better addressed. We performed a non-invasive, meta bolomicsbased screening of saliva from infants with congenital Zika syndrome (CZS), born from mothers that were infected with ZIKV during pregnancy. We were able to identify three biomarkers that suggest that this population suffered from an important inflammatory process; with the detection of mediators associated with glial activation, we propose that microcephaly is a product of immune response to the virus, as well as excitotoxicity mechanisms, which remain ongoing even after birth. (AU)

• Processo FAPESP: 18/03321-6 - Uma visão geral da metabolômica e lipidômica do plasma de pacientes com Doença de Alzheimer para rastreamento de biomarcadores ligados à demência
• Beneficiário: Carlos Fernando Odir Rodrigues Melo
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado
• Processo FAPESP: 11/50400-0 - Metabolismo energético, estado redox e funcionalidade mitocondrial na morte celular e em desordens cardiometabólicas e neurodegenerativas
• Beneficiário: Aníbal Eugênio Vercesi
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
• Beneficiário: Licio Augusto Velloso
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 16/17066-2 - Metabolômica e lipidômica do Zika vírus, do mosquito ao paciente
• Beneficiário: Carlos Fernando Odir Rodrigues Melo
• Modalidade de apoio: Bolsas no Brasil - Doutorado