Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Bioinformatics analysis of circulating miRNAs related to cancer following spinal cord injury

Texto completo
Autor(es):
Lopes, Elisangela C. P. [1] ; Paim, Layde R. [1] ; Matos-Souza, Jose R. [1] ; Calegari, Decio R. [2] ; Gorla, Jose I. [3] ; Cliquet, Jr., Alberto [4, 5] ; Lima, Carmen S. P. [1] ; McDonald, John F. [6] ; Nadruz, Jr., Wilson [1] ; Schreiber, Roberto [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Campinas, SP - Brazil
[2] Univ Maringa, Sch Phys Educ, Maringa, Parana - Brazil
[3] Univ Estadual Campinas, Sch Phys Educ, Campinas, SP - Brazil
[4] Univ Sao Paulo, Dept Elect Engn, Sao Carlos, SP - Brazil
[5] Univ Estadual Campinas, Fac Med Sci, Dept Orthoped, Campinas, SP - Brazil
[6] Georgia Inst Technol, Sch Biol, Petit Inst Bioengn & BioSci, Atlanta, GA 30332 - USA
Número total de Afiliações: 6
Tipo de documento: Artigo Científico
Fonte: BIOSCIENCE REPORTS; v. 39, n. 9 SEP 20 2019.
Citações Web of Science: 0
Resumo

Patients with spinal cord injury (SCI) have an increased risk of developing esophageal, bladder and hematologic malignancies compared with the normal population. In the present study, we aimed to identify, through in silico analysis, miRNAs and their target genes related to the three most frequent types of cancer in individuals with SCI. In a previous study, we reported a pattern of expression of miRNAs in 17 sedentary SCI males compared with 22 healthy able-bodied males by TaqMan OpenArray. This list of miRNAs deregulated in SCI patients was uploaded to miRWALK2.0 to predict the target genes and pathways of selected miRNAs. We used Cytoscape software to construct the network displaying the miRNAs and their gene targets. Among the down-regulated miRNAs in SCI, 21, 19 and 20 miRNAs were potentially associated with hematological, bladder and esophageal cancer, respectively, and three target genes (TP53, CCND1 and KRAS) were common to all three types of cancer. The three up-regulated miRNAs were potentially targeted by 18, 15 and 10 genes associated with all three types of cancer. Our current bioinformatics analysis suggests the potential influence of several miRNAs on the development of cancer in SCI. In general, these data may provide novel information regarding potential molecular mechanisms involved in the development of cancer among individuals with SCI. Further studies aiming at understanding how miRNAs contribute to the development of the major cancers that affect patients after SCI may help elucidate the role of these molecules in the pathophysiology of the disease. (AU)

Processo FAPESP: 17/23563-1 - Expressão de microRNAs e sua relação com hipertrofia cardíaca em pacientes hipertensos
Beneficiário:Roberto Schreiber
Linha de fomento: Auxílio à Pesquisa - Regular