Melatonin Supplementation Attenuates the Pro-Inflammatory Adipokines Expression in Visceral Fat from Obese Mice Induced by A High-Fat Diet

Autor(es)

Mendes de Farias, Talita da Silva ^[1] ; da Paixao, Regislane Ino ^[1] ; Cruz, Maysa Mariana ^[1] ; Cavalcante da Cunha de Sa, Roberta Dourado ^[1] ; Simao, Jussara de Jesus ^[1] ; Antraco, Vitor Jaco ^[1] ; Cardoso Alonso-Vale, Maria Isabel ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, BR-09913130 Diadema - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CELLS; v. 8, n. 9 SEP 2019.
• Citações Web of Science: 0

Resumo

Obesity is defined as a condition of abnormal or excessive fat accumulation in white adipose tissue that results from the exacerbated consumption of calories associated with low energy expenditure. Fat accumulation in both adipose tissue and other organs contributes to a systemic inflammation leading to the development of metabolic disorders such as type 2 diabetes, hypertension, and dyslipidemia. Melatonin is a potent antioxidant and improves inflammatory processes and energy metabolism. Using male mice fed a high-fat diet (HFD-59% fat from lard and soybean oil; 9:1) as an obesity model, we investigated the effects of melatonin supplementation on the prevention of obesity-associated complications through an analysis of plasma biochemical profile, body and fat depots mass, adipocytes size and inflammatory cytokines expression in epididymal (EPI) adipose depot. Melatonin prevented a gain of body weight and fat depot mass as well as adipocyte hypertrophy. Melatonin also reversed the increase of total cholesterol, triglycerides and LDL-cholesterol. In addition, this neurohormone was effective in completely decreasing the inflammatory cytokines leptin and resistin in plasma. In the EPI depot, melatonin reversed the increase of leptin, Il-6, Mcp-1 and Tnf-alpha triggered by obesity. These data allow us to infer that melatonin presents an anti-obesity effect since it acts to prevent the progression of pro-inflammatory markers in the epididymal adipose tissue together with a reduction in adiposity. (AU)

• Processo FAPESP: 15/03554-2 - Os efeitos da suplementação com melatonina no quadro do desenvolvimento da obesidade em camundongos
• Beneficiário: Talita da Silva Mendes de Farias Carvalho
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 16/07638-9 - Efeito da suplementação com melatonina no processo de transdiferenciação do tecido adiposo branco em tecido adiposo marrom em camundongos obesos
• Beneficiário: Talita da Silva Mendes de Farias Carvalho
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 18/05485-6 - Efeitos da dieta hiperlipídica e da suplementação com ácidos graxos ômega-7 e ômega-3 sobre o processo de browning, proliferação e diferenciação de células mesenquimais contidas na fração celular estromal do tecido adiposo
• Beneficiário: Maria Isabel Cardoso Alonso-Vale
• Modalidade de apoio: Auxílio à Pesquisa - Regular