| Texto completo | |
| Autor(es): |
Maximo Daneluti, Andre Luis
[1]
;
Neto, Francisco Mariano
[2]
;
Ruscinc, Nadia
[1]
;
Lopes, Ingrid
[1]
;
Robles Velasco, Maria Valeria
[1]
;
Matos, Jivaldo Do Rosario
[3]
;
Baby, Andre Rolim
[1]
;
Kalia, Yogeshvar N.
[4, 5]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Phys, BR-05508090 Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, Sao Paulo - Brazil
[4] Univ Geneva, Sch Pharmaceut Sci, 1 Rue Michel Servet, CH-1211 Geneva - Switzerland
[5] Univ Lausanne, 1 Rue Michel Servet, CH-1211 Geneva - Switzerland
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | International Journal of Pharmaceutics; v. 570, OCT 30 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Avobenzone (AVO), oxybenzone (OXY), and octyl methoxycinnamate (OMC), are widely used UV filters. The aim of this study was to investigate the effect of incorporation in mesoporous silica (SBA-15) on their cutaneous deposition and permeation. Stick formulations containing ``free{''} and ``incorporated{''} UV filters (SF1 and SF2, respectively) were prepared and characterized with respect to their physicochemical, thermal, and functional properties. Cutaneous delivery experiments using porcine skin with quantification by UHPLC-MS/MS, demonstrated that skin deposition of AVO and OXY after application of SF2 for 6 and 12 h was significantly lower than that from SF1 at each time-point (Student t-test, p < 0.05): e.g. OXY permeation across the skin was 30-, 12- and 1.5-fold lower after 6, 12 and 24 h, respectively, following application of SF2. Cutaneous biodistribution profiles of AVO and OXY to 800 mu m evidenced a significant decrease in the amounts in the viable epidermis and dermis. In contrast, deposition of the more lipophilic OMC was not significantly different (p > 0.05). In vitro photoprotective efficacy results demonstrated that adsorption/entrapment of UV filters enhanced the sun protection factor by 94%. In conclusion, SBA-15, an innovative mesoporous material, increased photoprotection by UV filters while reducing their cutaneous penetration and transdermal permeation. (AU) | |
| Processo FAPESP: | 13/18689-5 - Influência de compostos ativos / bioativo nos parâmetros físico-químicos e funcionais in vitro e in vivo de fotoprotetores labiais moldados |
| Beneficiário: | André Rolim Baby |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |