Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Imbalance of Steroid Hormones in Hamsters Infected with Schistosoma mansoni

Texto completo
Autor(es):
Oliveira, Katia C. [1] ; Cardoso, Rita [2] ; Dos Santos, Antonio C. [1] ; Fernandes, Ruben [3, 4] ; Botelho, Monica C. [2, 4]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Disciplina Parasitol, Sao Paulo - Brazil
[2] INSA, Natl Inst Hlth Dr Ricardo Jorge, Dept Hlth Promot & Chron Dis, Porto - Portugal
[3] Inst Politecn Porto, ESS, Porto - Portugal
[4] Univ Porto, Inst Invest & Inovacao, I35, Porto - Portugal
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS; v. 19, n. 8, p. 1122-1126, 2019.
Citações Web of Science: 1
Resumo

Objective: Schistosomiasis is a debilitating disease that affects 200 million people worldwide. Schistosoma haematobium and Schistosoma mansoni are the major causative agents of this disease. Cancer-association and infertility-association in Schistosoma haematobium infection have already been described and it is known that the parasite produces a catechol-estrogen molecule that induces a hormonal imbalance in the host. Methods: In order to better understand the relation of hormonal imbalance in experimental Schistosoma mansoni infection, we investigated a serum panel of steroid hormones in Schistosoma mansoni infected hamsters. Results: We found a decrease in the serum levels of Estradiol (E2), Testosterone and Progesterone in infected females and an increase of Testosterone and a decrease in Progesterone in infected males in comparison with controls. Conclusion: These results indicate that S. mansoni alters the levels of steroid hormones in infected males and females and it will increase the repertoire of data about the host-parasite molecular interplay and its relation with the endocrine system. (AU)

Processo FAPESP: 12/50115-6 - Estudo das vias de transdução de sinal em Schistosoma mansoni e sua relevância na interação parasita-hospedeiro (schisto-sig)
Beneficiário:Katia Cristina Pereira Oliveira Santos
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores