Caudate volume differences among treatment responders, non-responders and controls in children with obsessive-compulsive disorder

Autor(es)

Vattimo, Edoardo F. Q. ^[1] ; Barros, Vivian B. ^[2] ; Requena, Guaraci ^[3] ; Sato, Joao R. ^[4] ; Fatori, Daniel ^[1] ; Miguel, Euripedes C. ^[5] ; Shavitt, Roseli G. ^[1] ; Hoexter, Marcelo Q. ^[5] ; Batistuzzo, Marcelo C. ^[5]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept & Inst Psychiat, Hosp Clin HCFMUSP, Fac Med, R Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Dept Stat, Inst Math & Stat, Sao Paulo, SP - Brazil

^[4] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil

^[5] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY; v. 28, n. 12, p. 1607-1617, DEC 2019.
• Citações Web of Science: 1

Resumo

Treatment response in obsessive-compulsive disorder (OCD) is heterogeneous and the neurobiological underpinnings of such variability are unknown. To investigate this issue, we looked for differences in brain structures possibly associated with treatment response in children with OCD. 29 children with OCD (7-17 years) and 28 age-matched controls underwent structural magnetic resonance imaging. Patients then received treatment with fluoxetine or group cognitive-behavioral therapy during 14 weeks, and were classified as treatment responders or non-responders. The caudate nucleus, thalamus and orbitofrontal cortex were selected a priori, according to previous evidence of their association with OCD and its treatment. Gray matter (GM) volume comparisons between responders, non-responders and controls were performed, controlling for total GM volume. 17 patients were classified as responders. Differences among responders, non-responders and controls were found in both caudate nuclei (both p-values=0.041), but after Bonferroni correction for multiple comparisons, these findings were non-significant. However, after excluding the effect of an outlier, findings were significant for the right caudate (p=0.004). Pairwise comparisons showed larger caudate GM volume in responders versus non-responders and controls, bilaterally. The right caudate accounted for 20.2% of the variance in Y-BOCS changes after treatment in a linear regression model, with a positive correlation (p=0.016). We present a possible neural substrate for treatment response in pediatric OCD, which is in line with previous evidence regarding the caudate nucleus. Considering the limitations, further research is needed to replicate this finding and elucidate the heterogeneity of treatment response in children with OCD. (AU)

• Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
• Beneficiário: Andrea Parolin Jackowski
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/21934-5 - Estatística de redes: teoria, métodos e aplicações
• Beneficiário: André Fujita
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/04654-9 - Séries temporais, ondaletas e dados de alta dimensão
• Beneficiário: Pedro Alberto Morettin
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
• Beneficiário: Eurípedes Constantino Miguel Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 09/09949-8 - Ativação cerebral associada à memória episódica verbal no Transtorno Obsessivo-Compulsivo (TOC): análise por ressonância magnética funcional
• Beneficiário: Marcelo Camargo Batistuzzo
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto