| Texto completo | |
| Autor(es): Mostrar menos - |
de Souza, Ana Luiza R.
[1, 2]
;
Fonseca, Mariana
[1]
;
Barboza Ferreira, Leonardo Miziara
[1, 2]
;
Kurokawa, Suzy S. S.
[1]
;
Kiill, Charlene P.
[2]
;
Ferreira, Natalia N.
[2]
;
Pyrrho, Alexandre dos Santos
[3]
;
Sarmento, Victor H. V.
[4]
;
Silva, Amelia M.
[5, 6]
;
Gremiao, Maria Palmira D.
[2]
;
Ribeiro, Clovis A.
[1]
Número total de Autores: 11
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Inst Chem, R Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP - Brazil
[3] Fed Univ Rio de Janeiro UFRJ, Dept Clin & Toxicol Anal, Fac Pharm, Av Carlos Chagas Filho 373, BR-21941902 Rio De Janeiro, RJ - Brazil
[4] Fed Univ Sergipe UFS, Dept Chem, Campus Prof Alberto de Carvalho, BR-49500000 Itabaiana, SE - Brazil
[5] Univ Tras Os Montes & Alto Douro UTAD, Dept Biol & Environm, Quinta Prados 1013, P-5001801 Vila Real - Portugal
[6] Univ Tras Os Montes & Alto Douro UTAD, Ctr Res & Technol Agroenvironm & Biol Sci CITAB, Quinta Prados 1013, P-5001801 Vila Real - Portugal
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | COLLOIDS AND SURFACES B-BIOINTERFACES; v. 184, DEC 1 2019. |
| Citações Web of Science: | 0 |
| Resumo | |
Hexagonal liquid crystals and supramolecular polymers from meglumine-based supra-amphiphiles were developed as drug delivery systems to be applied on the skin. The influence of fatty acid unsaturation on the structure and mechanical properties was evaluated. Moreover, we have investigated the system biocompatibility and how the type of water could influence its bioadhesive properties. Meglumine-oleic acid (MEG-OA) was arranged as hexagonal liquid crystals at 30-70 wt% water content, probably due to its curvature and increased water solubility. Meglumine-stearic acid (MEG-SA) at 10-80 wt% water content self-assembled as a lamellar polymeric network, which can be explained by the low mobility of MEG-SA in water due to hydrophobic interactions between fatty acid chains and H-bonds between meglumine and water molecules. Both systems have shown suitable mechanical parameters and biocompatibility, making them potential candidates to encapsulate therapeutic molecules for skin delivery. Moreover, a strong positive correlation between the amount of unfrozen bound water in meglumine-based systems and the bioadhesion properties was observed. This work shows that a better understanding of the physicochemical properties of a drug delivery system is extremely important for the correlation with the desired biological response and, thus, improve the product performance for biomedical applications. (AU) | |
| Processo FAPESP: | 13/08411-0 - Comportamento de fases e propriedades termoreológicas de géis anfifílicos a base de meglumina potencialmente aplicáveis como materiais bioadesivos |
| Beneficiário: | Clovis Augusto Ribeiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |