ADP-ribosylation: from molecular mechanisms to human disease

Autor(es)

Hoch, Nicolas C. ^[1] ; Polo, Luis M. ^{[2, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil

^[2] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Canc Res UK DNA Repair Enzymes Grp, Brighton, E Sussex - England

^[3] Consejo Nacl Invest Cient & Tecn, Inst Histol & Embryol Mendoza, Mendoza - Argentina

• Tipo de documento: Artigo de Revisão
• Fonte: GENETICS AND MOLECULAR BIOLOGY; v. 43, n. 1, 1 2020.
• Citações Web of Science: 0

Resumo

Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD(+) as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration. (AU)

• Processo FAPESP: 18/18007-5 - ADP-ribosilação de proteínas: sinalização de danos ao DNA e impactos na saúde humana
• Beneficiário: Nicolas Carlos Hoch
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores