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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

First identification of mammalian orthoreovirus type 3 by gut virome analysis in diarrheic child in Brazil

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Autor(es):
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Rosa, Ulisses Alves [1] ; Ribeiro, Geovani de Oliveira [1] ; Villanova, Fabiola [1] ; Luchs, Adriana [2] ; de Padua Milagres, Flavio Augusto [3, 4, 5] ; Komninakis, Shirley Vasconcelos [6, 7] ; Tahmasebi, Roozbeh [8, 9] ; Brito Sayao Lobato, Marcia Cristina Alves [3, 5] ; Brustulin, Rafael [3, 4, 5] ; das Chagas, Rogerio Togisaki [3, 5] ; Neves dos Santos Abrao, Maria de Fatima [3, 5] ; de Deus Alves Soares, Cassia Vitoria [3, 5] ; Tinker, Rory J. [9, 10] ; Pandey, Ramendra Pati [11] ; Raj, V. Samuel [11] ; Sabino, Ester Cerdeira [9, 12] ; Deng, Xutao [13, 14] ; Delwart, Eric [13, 14] ; da Costa, Antonio Charlys [9] ; Leal, Elcio [1]
Número total de Autores: 20
Afiliação do(s) autor(es):
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[1] Fed Univ Para, Inst Biol Sci, BR-66075000 Belem, Para - Brazil
[2] Adolfo Lutz Inst, Virol Ctr, Enter Dis Lab, BR-01246000 Sao Paulo, SP - Brazil
[3] Secretary Hlth Tocantins, BR-77453000 Tocantins - Brazil
[4] Fed Univ Tocantins, Inst Biol Sci, BR-77001090 Tocantins - Brazil
[5] Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins - Brazil
[6] Univ Fed Sao Paulo, Retrovirol Lab, BR-04023062 Sao Paulo - Brazil
[7] Fac Med ABC, Postgrad Program Hlth Sci, BR-09060870 Santo Andre, SP - Brazil
[8] Univ Sao Paulo, Polytech Sch, Sao Paulo, SP - Brazil
[9] Univ Sao Paulo, Inst Med Trop, BR-05403000 Sao Paulo, SP - Brazil
[10] Univ Manchester, Fac Biol Med & Hlth, Manchester M13 9PL, Lancs - England
[11] SRM Univ, C4D, Delhi NCR, Sonepat 131029, Haryana - India
[12] Univ Sao Paulo, Fac Med, LIM 46, BR-01246903 Sao Paulo, SP - Brazil
[13] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA
[14] Vitalant Res Inst, San Francisco, CA 94143 - USA
Número total de Afiliações: 14
Tipo de documento: Artigo Científico
Fonte: SCIENTIFIC REPORTS; v. 9, DEC 9 2019.
Citações Web of Science: 0
Resumo

Diarrhea remains one of the most common causes of deaths in children. Although many studies have investigated the prevalence of enteric pathogens around the globe some diarrheal episodes remain unexplained. It is possible that some yet-unidentified viral agents could be related to these cases of gastroenteritis. By using viral metagenomics techniques, we screened 251 fecal samples of children between 0.5 to 2.5-year-old with acute diarrhea not associated with common pathogens. These children live in rural areas and have different levels of contact with animals such as pigs, cows and bats. Here we report a complete genome of one mammalian orthoreovirus (MRV) type 3, denoted TO-151/BR, detected in a female child in the state of Tocantins (north of Brazil). Brazilian TO-151/BR strain was classified as MRV-3 based on S1 phylogeny and was closely related to porcine Asian strains. Phylogenetic analyses showed that other segments were more similar to MRV-3s of different geographic locations and hosts, including human and bats, highlighting genome reassortment and lack of host-specific barriers. This is the first report of MRV-3 in South America and a hypothesis of a silent long-term circulation of this virus in Brazil has been raised. (AU)

Processo FAPESP: 15/12944-9 - Investigando a evolução de cepas animais de rotavírus infectando humanos
Beneficiário:Adriana Luchs
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 17/00021-9 - Metagenômica viral da dengue, Chikungunya e Zika: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Antonio Charlys da Costa
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 16/01735-2 - Metagenômica viral de dengue, Chikungunya e Zika vírus: acompanhar, explicar e prever a transmissão e distribuição espaço-temporal no Brasil
Beneficiário:Ester Cerdeira Sabino
Linha de fomento: Auxílio à Pesquisa - Regular