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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Association between spontaneous activity of the default mode network hubs and leukocyte telomere length in late childhood and early adolescence

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Autor(es):
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Rebello, Keila [1] ; Moura, Luciana M. [1, 2] ; Xavier, Gabriela [3] ; Spindola, Leticia M. [4, 2, 3] ; Carvalho, Carolina Muniz [4, 3] ; Hoexter, Marcelo Queiroz [5, 2] ; Gadelha, Ary [4, 2] ; Picon, Felipe [6, 2] ; Pan, Pedro Mario [4, 2] ; Zugman, Andre [4, 2] ; Grassi-Oliveira, Rodrigo [2, 7] ; Brietzke, Elisa [8, 9] ; Belangero, I, Sintia ; Salum, Giovanni Abrahao [6, 10] ; Rohde, Luis Augusto [6, 10] ; Miguel, Euripedes Constantino [5, 10] ; Bressan, Rodrigo [11, 10] ; Jackowski, Andrea [11, 10] ; Sato, Joao Ricardo [1, 10]
Número total de Autores: 19
Afiliação do(s) autor(es):
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[1] Univ Fed ABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
[2] Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil
[3] I, Univ Fed Sao Paulo, Dept Morphol & Genet, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, Dept Psychiat, Sao Paulo, SP - Brazil
[6] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Psychiat, Porto Alegre, RS - Brazil
[7] Pontificia Univ Catolica Rio Grande do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS - Brazil
[8] Univ Fed Sao Paulo, Programa Posgrad Psiquiatria & Psicol Med, Sao Paulo, SP - Brazil
[9] Queens Univ, Sch Med, Dept Psychiat, Kingston, ON - Canada
[10] Belangero, Sintia, I, Natl Inst Dev Psychiat Children & Adolescents INP, Sao Paulo, SP - Brazil
[11] Belangero, Sintia, I, Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP - Brazil
Número total de Afiliações: 11
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF PSYCHOSOMATIC RESEARCH; v. 127, DEC 2019.
Citações Web of Science: 0
Resumo

The impact of early life stress on mental health and telomere length shortening have been reported. Changes in brain default mode network (DMN) were found to be related to a myriad of psychiatric conditions in which stress may play a role. In this context, family environment and adverse childhood experiences (ACEs) are potential causes of stress. This is a hypothesis-driven study focused on testing two hypotheses: (i) there is an association between telomere length and the function of two main hubs of DMN: the posterior cingulate cortex (PCC) and the medial prefrontal cortex (mPFC); (ii) this association is modulated by family environment and/or ACEs. To the best of our knowledge, this is the first study investigating these hypotheses. Resting-state functional magnetic resonance imaging data and blood sample were collected from 389 subjects (6-15 age range). We assessed DMN fractional amplitude of low-frequency fluctuations (fALFF) and leukocyte telomere length (LTL). We fitted general linear models to test the main effects of LTL on DMN hubs and the interaction effects with Family Environment Scale (FES) and ACEs. The results did not survive a strict Bonferroni correction. However, uncorrected p-values suggest that LTL was positively correlated with fALFF in PCC and a FES interaction between FES and LTL at mPFC. Although marginal, our results encourage further research on the interaction between DMN hubs, telomere length and family environment, which may play a role on the biological embedding of stress. (AU)

Processo FAPESP: 13/08531-5 - Coorte de alto risco para transtornos psiquiátricos na infância: seguimento de neuroimagem após 3 anos
Beneficiário:Andrea Parolin Jackowski
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/21934-5 - Estatística de redes: teoria, métodos e aplicações
Beneficiário:André Fujita
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/50917-0 - INCT 2014: psiquiatria do desenvolvimento para crianças e adolescentes
Beneficiário:Eurípedes Constantino Miguel Filho
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 14/07280-1 - Busca por marcadores genéticos de risco, de progressão e de reposta ao tratamento na esquizofrenia
Beneficiário:Síntia Iole Nogueira Belangero
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 18/04654-9 - Séries temporais, ondaletas e dados de alta dimensão
Beneficiário:Pedro Alberto Morettin
Linha de fomento: Auxílio à Pesquisa - Temático